Multianalyte Digital Enzyme Biosensors with Built-in Boolean Logic

被引：85

作者：

Katz, Evgeny ^{[1
]}

Wang, Joseph ^{[2
]}

Privman, Marina ^{[3
]}

Halamek, Jan ^{[1
]}

机构：

[1] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA

[2] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

[3] SUNY Empire State Coll, Ft Drum, NY 13602 USA

来源：

ANALYTICAL CHEMISTRY | 2012年 / 84卷 / 13期

基金：

美国国家科学基金会;

关键词：

TRAUMATIC BRAIN-INJURY; BIOMARKER; SIGNALS; SYSTEMS; PROTEIN; GATES;

D O I：

10.1021/ac3007076

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Novel biosensors based on the biocomputing concept digitally process multiple biochemical signals through Boolean logic networks of coupled biomolecular reactions and produce output in the form of a YES/NO response. Compared to traditional single-analyte sensing devices, biocomputing approach enables a high-fidelity multianalyte biosensing, particularly beneficial for biomedical applications. © 2012 American Chemical Society.

引用

页码：5463 / 5469

页数：7

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