Minimally invasive protein delivery with rapidly dissolving polymer microneedles

被引：338

作者：

Sullivan, Sean P.

Murthy, Niren ^{[1
,2
]}

Prausnitz, Mark R. ^{[1
,3
]}

机构：

[1] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 05期

关键词：

D O I：

10.1002/adma.200701205

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A new room-temperature, in situ polymerization process to produce microneedles (see figure), which can encapsulate functional bioniolecules and dissolve within minutes, is presented. The dissolution rate and mechanical strength of these polymer microneedles can be tailored by changing monomer composition and microneedle geometry. Drug delivery using micrometer-scale needles that dissolve in the skin could eliminate the pain and dangers of hypodermic needle use.

引用

收藏

页码：933 / +

页数：7

相关论文

共 23 条

[1]

Vinylpyrrolidone-co-(meth) acrylic acid inserts for ocular drug delivery:: Synthesis and evaluation [J].

Barbu, E ;

Sarvaiya, I ;

Green, KL ;

Nevell, TG ;

Tsibouklis, J .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 74A (04) :598-606

[2]

Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force [J].

Davis, SP ;

Landis, BJ ;

Adams, ZH ;

Allen, MG ;

Prausnitz, MR .

JOURNAL OF BIOMECHANICS, 2004, 37 (08) :1155-1163

[3]

GILL HS, IN PRESS CLIN J PAIN

[4]

Feasibility of microneedles for percutaneous absorption of insulin [J].

Ito, Yukako ;

Hagiwara, Eiji ;

Saeki, Atsushi ;

Sugioka, Nobuyuki ;

Takada, Kanji .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 29 (01) :82-88

[5]

Lack of pain associated with microfabricated microneedles [J].

Kaushik, S ;

Hord, AH ;

Denson, DD ;

McAllister, DV ;

Smitra, S ;

Allen, MG ;

Prausnitz, MR .

ANESTHESIA AND ANALGESIA, 2001, 92 (02) :502-504

[6]

Langer R, 1998, NATURE, V392, P5

[7]

Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux®) technology [J].

Lin, WQ ;

Cormier, M ;

Samiee, A ;

Griffin, A ;

Johnson, B ;

Teng, CL ;

Hardee, GE ;

Daddona, PE .

PHARMACEUTICAL RESEARCH, 2001, 18 (12) :1789-1793

[8]

Transdermal delivery of insulin using microneedles in vivo [J].

Martanto, W ;

Davis, SP ;

Holiday, NR ;

Wang, J ;

Gill, HS ;

Prausnitz, MR .

PHARMACEUTICAL RESEARCH, 2004, 21 (06) :947-952

[9]

Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies [J].

McAllister, DV ;

Wang, PM ;

Davis, SP ;

Park, JH ;

Canatella, PJ ;

Allen, MG ;

Prausnitz, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :13755-13760

[10]

Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery [J].

Mikszta, JA ;

Alarcon, JB ;

Brittingham, JM ;

Sutter, DE ;

Pettis, RJ ;

Harvey, NG .

NATURE MEDICINE, 2002, 8 (04) :415-419