Indirect allorecognition: Not simple but effective

被引：13

作者：

Bolton, Eleanor M. ^{[1
]}

Bradley, J. Andrew

Pettigrew, Gavin J.

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 2QQ, England

来源：

TRANSPLANTATION | 2008年 / 85卷 / 05期

基金：

英国惠康基金;

关键词：

indirect allorecognition; helper CD4 T cells; chronic rejection;

D O I：

10.1097/TP.0b013e3181664db3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Donor dendritic cells are potent but short-lived stimulators of early transplant rejection, and recipient antigen presenting cells presenting donor major histocompatibility complex peptides sustain immunoreactivity and contribute to chronic rejection. We briefly consider how CD4 T cells that recognize allopeptide can provide help for effector and regulatory responses and highlight the implications for promoting graft survival.

引用

页码：667 / 669

页数：3

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