BDNF genotype potentially modifying the association between incident stroke and depression

被引：49

作者：

Kim, Jae-Min ^{[2
,3
]}

Stewart, Robert ^{[1
]}

Kim, Sung-Wan ^{[2
,3
]}

Yang, Su-Jin ^{[2
,3
]}

Shina, Il-Seon ^{[2
,3
]}

Kim, Young-Hoon ^{[4
]}

Yoon, Jin-Sang ^{[2
,3
]}

机构：

[1] Kings Coll London, Inst Psychiat, Epidemiol Sect, London WC2R 2LS, England

[2] Chonnam Natl Univ, Sch Med, Dept Psychiat, Kwangju, South Korea

[3] Chonnam Natl Univ, Sch Med, Depress Clin Res Ctr, Kwangju, South Korea

[4] Inje Univ, Dept Neuropsychiat, Sch Med, Paik Inje Mem Clin Res Inst, Pusan, South Korea

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 05期

关键词：

brain-derived neurotropbic factor; stroke; depression; genetics;

D O I：

10.1016/j.neurobiolaging.2006.11.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression. Method: Five hundred community residents aged > 65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline. Results: The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function. Conclusion: The BDNF val66met polymorphism may modify the association between stroke and depression. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：789 / 792

页数：4

共 15 条

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[2] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].