Ubiquitylation of DNA polymerase λ

被引：12

作者：

Markkanen, Enni ^{[1
]}

van Loon, Barbara ^{[1
]}

Ferrari, Elena ^{[1
]}

Huebscher, Ulrich ^{[1
]}

机构：

[1] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

来源：

FEBS LETTERS | 2011年 / 585卷 / 18期

基金：

瑞士国家科学基金会;

关键词：

DNA polymerase lambda; Posttranslational modifications; Regulation; Oxidation damage; Ubiquitylation; BASE EXCISION-REPAIR; REPLICATION PROTEIN-A; CELL NUCLEAR ANTIGEN; STRAND MISALIGNMENT; POL LAMBDA; X-FAMILY; PHOSPHORYLATION; SENSITIVITY; FIDELITY; BYPASS;

D O I：

10.1016/j.febslet.2011.03.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerase (pol) lambda, one of the 15 cellular pols, belongs to the X family. It is a small 575 amino-acid protein containing a polymerase, a dRP-lyase, a proline/serine rich and a BRCT domain. Pol lambda shows various enzymatic activities including DNA polymerization, terminal transferase and dRP-lyase. It has been implicated to play a role in several DNA repair pathways, particularly base excision repair (BER), non-homologous end-joining (NHEJ) and translesion DNA synthesis (TLS). Similarly to other DNA repair enzymes, pol lambda undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization. Here we describe our knowledge about ubiquitylation of pol lambda and the impact of this modification on its regulation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2826 / 2830

页数：5

共 45 条

[1] A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification [J].

Almeida, Karen H. ;

Sobol, Robert W. .

DNA REPAIR, 2007, 6 (06) :695-711

[2] The frameshift infidelity of human DNA polymerase λ -: Implications for function [J].

Bebenek, K ;

Garcia-Diaz, M ;

Blanco, L ;

Kunkel, TA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (36) :34685-34690

[3] Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ [J].

Bebenek, Katarzyna ;

Garcia-Diaz, Miguel ;

Foley, Meredith C. ;

Pedersen, Lars C. ;

Schlick, Tamar ;

Kunkel, Thomas A. .

EMBO REPORTS, 2008, 9 (05) :459-464

[4] Cutting edge:: DNA polymerases μ and λ are dispensable for Ig gene hypermutation [J].

Bertocci, B ;

De Smet, A ;

Flatter, E ;

Dahan, A ;

Bories, JC ;

Landreau, C ;

Weill, JC ;

Reynaud, CA .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :3702-3706

[5] Nonoverlapping functions of DNA polymerases Mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo [J].

Bertocci, Barbara ;

De Smet, Annie ;

Weill, Jean-Claude ;

Reynaud, Claude-Agnes .

IMMUNITY, 2006, 25 (01) :31-41

[6] DNA polymerase λ protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair [J].

Braithwaite, EK ;

Kedar, PS ;

Lan, L ;

Polosina, YY ;

Asagoshi, K ;

Poltoratsky, VP ;

Horton, JK ;

Miller, H ;

Teebor, GW ;

Yasui, A ;

Wilson, SH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (36) :31641-31647

[7] DNA polymerase λ mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts [J].

Braithwaite, EK ;

Prasad, R ;

Shock, DD ;

Hou, EW ;

Beard, WA ;

Wilson, SH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) :18469-18475

[8] Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis [J].

Brown, Jessica A. ;

Pack, Lindsey R. ;

Sanman, Laura E. ;

Suo, Zucai .

DNA REPAIR, 2011, 10 (01) :24-33

[9] The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway [J].

Capp, Jean-Pascal ;

Boudsocq, Francois ;

Bergoglio, Valerie ;

Trouche, Didier ;

Cazaux, Christophe ;

Blanco, Luis ;

Hoffmann, Jean-Sebastien ;

Canitrot, Yvan .

CARCINOGENESIS, 2010, 31 (10) :1742-1747

[10] Error-free bypass of 2-hydroxyadenine by human DNA polymerase λ with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts [J].

Crespan, Emmanuele ;

Huebscher, Ulrich ;

Maga, Giovanni .

NUCLEIC ACIDS RESEARCH, 2007, 35 (15) :5173-5181

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