Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic

被引：57

作者：

Duits, Flora H. ^{[1
,2
]}

Prins, Niels D. ^{[1
,2
]}

Lemstra, Afina W. ^{[1
,2
]}

Pijnenburg, Yolande A. L. ^{[1
,2
]}

Bouwman, Femke H. ^{[1
,2
]}

Teunissen, Charlotte E. ^{[3
,4
]}

Scheltens, Philip ^{[1
,2
]}

van der Flier, Wiesje M. ^{[1
,2
,5
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Clin Chem, Neurochem Lab, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Biobank, Amsterdam, Netherlands

[5] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 05期

关键词：

Dementia; Alzheimer's disease; Clinical practice; Diagnostic impact; Assessment of cognitive disorders; Cerebrospinal fluid; Amyloid-beta(1-42); Tau; Biomarkers; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID BIOMARKERS; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; RESEARCH CRITERIA; DEMENTIA; RECOMMENDATIONS; GUIDELINES; MARKERS;

D O I：

10.1016/j.jalz.2014.05.1753

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: We aimed to assess the impact of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease on decision making and patient management in a tertiary memory clinic. Methods: We included all patients, for 1 year, visiting the VUmc Alzheimer Center for cognitive screening. Neurologists completed questionnaires before and after CSF disclosure. We assessed the change of diagnosis, diagnostic confidence, and impact on patient management. Results: A total of 438 patients (age 63 +/- 8 years, 39% women) were included, of whom 351 (80%) underwent lumbar puncture. After the disclosure of CSF 23/351 diagnoses (7%) were changed. Diagnostic confidence increased from 84% to 89% (P < .001). There were consequences for management in 44/351 patients (13%) with CSF, and 13/87 patients (15%) because of unavailable CSF. There was no effect of age on these results. Conclusions: CSF biomarkers aid clinicians with decision making during diagnostic work-up of cognitive disorders. This study may be useful for developing guidelines for the implementation of CSF biomarkers in daily practice. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：523 / 532

页数：10

共 28 条

[11] Diagnostic Impact of CSF Biomarkers in a Local Hospital Memory Clinic [J].

Kester, Maartje I. ;

Boelaarts, Leo ;

Bouwman, Femke H. ;

Vogels, Raymond L. ;

Groot, Erwin R. ;

van Elk, Evert J. ;

Blankenstein, Marinus A. ;

van der Flier, Wiesje M. ;

Scheltens, Philip .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2010, 29 (06) :491-497

[12] Comparing Positron Emission Tomography Imaging and Cerebrospinal Fluid Measurements of β-Amyloid [J].

Landau, Susan M. ;

Lu, Ming ;

Joshi, Abhinay D. ;

Pontecorvo, Michael ;

Mintun, Mark A. ;

Trojanowski, John Q. ;

Shaw, Leslie M. ;

Jagust, William J. .

ANNALS OF NEUROLOGY, 2013, 74 (06) :826-836

[13]

Lijmer Jeroen G, 2009, Med Decis Making, V29, pE13, DOI 10.1177/0272989X09336144

[14] Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop [J].

Litvan, I ;

Agid, Y ;

Calne, D ;

Campbell, G ;

Dubois, B ;

Duvoisin, RC ;

Goetz, CG ;

Golbe, LI ;

Grafman, J ;

Growdon, JH ;

Hallett, M ;

Jankovic, J ;

Quinn, NP ;

Tolosa, E ;

Zee, DS ;

Chase, TN ;

FitzGibbon, EJ ;

Hall, Z ;

Juncos, J ;

Nelson, KB ;

Oliver, E ;

Pramstaller, P ;

Reich, SG ;

Verny, M .

NEUROLOGY, 1996, 47 (01) :1-9

[15] CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment [J].

Mattsson, Niklas ;

Zetterberg, Henrik ;

Hansson, Oskar ;

Andreasen, Niels ;

Parnetti, Lucilla ;

Jonsson, Michael ;

Herukka, Sanna-Kaisa ;

van der Flier, Wiesje M. ;

Blankenstein, Marinus A. ;

Ewers, Michael ;

Rich, Kenneth ;

Kaiser, Elmar ;

Verbeek, Marcel ;

Tsolaki, Magda ;

Mulugeta, Ezra ;

Rosen, Erik ;

Aarsland, Dag ;

Visser, Pieter Jelle ;

Schroeder, Johannes ;

Marcusson, Jan ;

de Leon, Mony ;

Hampel, Harald ;

Scheltens, Philip ;

Pirttilae, Tuula ;

Wallin, Anders ;

Jonhagen, Maria Eriksdotter ;

Minthon, Lennart ;

Winblad, Bengt ;

Blennow, Kaj .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (04) :385-393

[16] Diagnosis and management of dementia with Lewy bodies - Third report of the DLB consortium [J].

McKeith, IG ;

Dickson, DW ;

Lowe, J ;

Emre, M ;

O'Brien, JT ;

Feldman, H ;

Cummings, J ;

Duda, JE ;

Lippa, C ;

Perry, EK ;

Aarsland, D ;

Arai, H ;

Ballard, CG ;

Boeve, B ;

Burn, DJ ;

Costa, D ;

Del Ser, T ;

Dubois, B ;

Galasko, D ;

Gauthier, S ;

Goetz, CG ;

Gomez-Tortosa, E ;

Halliday, G ;

Hansen, LA ;

Hardy, J ;

Iwatsubo, T ;

Kalaria, RN ;

Kaufer, D ;

Kenny, RA ;

Korczyn, A ;

Kosaka, K ;

Lee, VMY ;

Lees, A ;

Litvan, I ;

Londos, E ;

Lopez, OL ;

Minoshima, S ;

Mizuno, Y ;

Molina, JA ;

Mukaetova-Ladinska, EB ;

Pasquier, F ;

Perry, RH ;

Schulz, JB ;

Trojanowski, JQ ;

Yamada, M .

NEUROLOGY, 2005, 65 (12) :1863-1872

[17] The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

McKhann, Guy M. ;

Knopman, David S. ;

Chertkow, Howard ;

Hyman, Bradley T. ;

Jack, Clifford R., Jr. ;

Kawas, Claudia H. ;

Klunk, William E. ;

Koroshetz, Walter J. ;

Manly, Jennifer J. ;

Mayeux, Richard ;

Mohs, Richard C. ;

Morris, John C. ;

Rossor, Martin N. ;

Scheltens, Philip ;

Carrillo, Maria C. ;

Thies, Bill ;

Weintraub, Sandra ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :263-269

[18] Impact of cerebro-spinal fluid biomarkers of Alzheimer's disease in clinical practice: a multicentric study [J].

Mouton-Liger, Francois ;

Wallon, David ;

Troussiere, Anne-Cecile ;

Yatimi, Rachida ;

Dumurgier, Julien ;

Magnin, Eloi ;

de la Sayette, Vincent ;

Duron, Emannuelle ;

Philippi, Nathalie ;

Beaufils, Emilie ;

Gabelle, Audrey ;

Croisile, Bernard ;

Robert, Philippe ;

Pasquier, Florence ;

Hannequin, Didier ;

Hugon, Jacques ;

Paquet, Claire .

JOURNAL OF NEUROLOGY, 2014, 261 (01) :144-151

[19] Amyloid-β(1-42), Total Tau, and Phosphorylated Tau as Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer Disease [J].

Mulder, Cees ;

Verwey, Nicolaas A. ;

van der Flier, Wiesje M. ;

Bouwman, Femke H. ;

Kok, Astrid ;

van Elk, Evert J. ;

Scheltens, Philip ;

Blankenstein, Marinus A. .

CLINICAL CHEMISTRY, 2010, 56 (02) :248-253

[20] Age and apolipoprotein E*4 allele effects on cerebrospinal fluid β-amyloid 42 in adults with normal cognition [J].

Peskind, Elaine R. ;

Li, Ge ;

Shofer, Jane ;

Quinn, Joseph F. ;

Kaye, Jeffrey A. ;

Clark, Chris M. ;

Farlow, Martin R. ;

DeCarli, Charles ;

Raskind, Murray A. ;

Schellenberg, Gerard D. ;

Lee, Virginia M. -Y. ;

Galasko, Douglas R. .

ARCHIVES OF NEUROLOGY, 2006, 63 (07) :936-939

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