Anterior gradient 2: A novel player in tumor cell biology

被引：143

作者：

Brychtova, Veronika ^{[1
]}

Vojtesek, Borivoj ^{[1
]}

Hrstka, Roman ^{[1
]}

机构：

[1] Masaryk Mem Canc Inst, Brno 65653, Czech Republic

来源：

CANCER LETTERS | 2011年 / 304卷 / 01期

关键词：

AGR2; Tumor metastasis; Breast cancer; Pancreatic cancer; Barrett esophagus; BREAST-CANCER PATIENTS; XENOPUS CEMENT GLAND; PROSTATE-CANCER; ESTROGEN-RECEPTOR; GENE-EXPRESSION; PANCREATIC-CANCER; HUMAN HOMOLOG; LUNG-CANCER; PROTEIN; AGR2;

D O I：

10.1016/j.canlet.2010.12.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

AGR2 has evolutionarily conserved roles in development and tissue regeneration and is linked with several human cancers. The exact functions and regulation of AGR2 are poorly understood, but current data identify AGR2 as a clinically relevant factor that modulates the behavior and response of hormone-dependent cancers (breast, prostate) and hormone-independent cancers (colorectal, pancreatic, esophageal and other common cancers). AGR2 protein expression induces metastasis, acts as a p53 tumor suppressor inhibitor and survival factor, participates directly in neoplastic transformation and is involved in drug resistance. Thus, AGR2 is an important tumor biomarker and negative prognostic factor potentially exploitable in clinical practice. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

共 43 条

[1]

Anterior specification of embryonic ectoderm:: the role of the Xenopus cement gland-specific gene XAG-2 [J].

Aberger, F ;

Weidinger, G ;

Grunz, H ;

Richter, K .

MECHANISMS OF DEVELOPMENT, 1998, 72 (1-2) :115-130

[2]

Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines [J].

Boonstra, Jurjen J. ;

van Marion, Ronald ;

Beer, David G. ;

Lin, Lin ;

Chaves, Paula ;

Ribeiro, Catarina ;

Pereira, A. Dias ;

Roque, Lucia ;

Darnton, S. Jane ;

Altorki, Nasser K. ;

Schrump, David S. ;

Klimstra, David S. ;

Tang, Laura H. ;

Eshleman, James R. ;

Alvarez, Hector ;

Shimada, Yutaka ;

van Dekken, Herman ;

Tilanus, Hugo W. ;

Dinjens, Winand N. M. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (04) :271-274

[3]

The development of androgen-independent prostate cancer [J].

Feldman, BJ ;

Feldman, D .

NATURE REVIEWS CANCER, 2001, 1 (01) :34-45

[4]

hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [J].

Fletcher, GC ;

Patel, S ;

Tyson, K ;

Adam, PJ ;

Schenker, M ;

Loader, JA ;

Daviet, L ;

Legrain, P ;

Parekh, R ;

Harris, AL ;

Terrett, JA .

BRITISH JOURNAL OF CANCER, 2003, 88 (04) :579-585

[5]

Fritzsche FR, 2007, HISTOL HISTOPATHOL, V22, P703, DOI 10.14670/HH-22.703

[6]

The pro-metastatic protein anterior gradient-2 predicts poor prognosis in tamoxifen-treated breast cancers [J].

Hrstka, R. ;

Nenutil, R. ;

Fourtouna, A. ;

Maslon, M. M. ;

Naughton, C. ;

Langdon, S. ;

Murray, E. ;

Larionov, A. ;

Petrakova, K. ;

Muller, P. ;

Dixon, M. J. ;

Hupp, T. R. ;

Vojtesek, B. .

ONCOGENE, 2010, 29 (34) :4838-4847

[7]

Iacobuzio-Donahue CA, 2003, CANCER RES, V63, P8614

[8]

Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients [J].

Innes, HE ;

Liu, D ;

Barraclough, R ;

Davies, MPA ;

O'Neill, PA ;

Platt-Higgins, A ;

Rudland, SD ;

Sibson, DR ;

Rudland, PS .

BRITISH JOURNAL OF CANCER, 2006, 94 (07) :1057-1065

[9]

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins [J].

Jessop, Catherine E. ;

Watkins, Rachel H. ;

Simmons, Jennifer J. ;

Tasab, Mohammed ;

Bulleid, Neil J. .

JOURNAL OF CELL SCIENCE, 2009, 122 (23) :4287-4295

[10]

Hormonal factors and pancreatic cancer in women [J].

Kreiger, N ;

Lacroix, J ;

Sloan, M .

ANNALS OF EPIDEMIOLOGY, 2001, 11 (08) :563-567

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