Sesterterpenes from the Tropical Sponge Coscinoderma sp.

被引：29

作者：

Bae, Jaemin ^{[4
]}

Jeon, Ju-eun ^{[4
]}

Lee, Yeon-Ju ^{[2
]}

Lee, Hyi-Seung ^{[2
]}

Sim, Chung J. ^{[3
]}

Oh, Ki-Bong ^{[1
]}

Shin, Jongheon ^{[4
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Coll Agr & Life Sci, Seoul 151921, South Korea

[2] Korea Ocean Res & Dev Inst, Marine Nat Prod Lab, Seoul 425600, South Korea

[3] Hannam Univ, Coll Life Sci & Nano Technol, Dept Biol Sci, Taejon 305811, South Korea

[4] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 08期

关键词：

MARINE SPONGE; INHIBITORS; SUVANINE; MATHEWSI; GROWTH; CHEMISTRY; SULFATES; ASSAY;

D O I：

10.1021/np200492k

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Eight new sesterterpenes (2, 5, and 10-15), including structurally related pentaprenyl hydroquinones (2 and 5), and seven known ones of the same structural classes were isolated from the sponge Coscinoderma sp., collected from Chuuk Island, Micronesia. On the basis of the results of combined spectroscopic analyses, the new compounds were determined to be derivatives of the halisulfates and suvanine. These compounds exhibited moderate cytotoxicity against the K562 cell line and inhibitory activities against isocitrate lyase, sortase A, and Na(+)/K(+)-ATPase; significant structure activity relationships were evident.

引用

页码：1805 / 1811

页数：7

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