Finding a Target for Resveratrol

被引：130

作者：

Tennen, Ruth I. ^{[1
,2
]}

Michishita-Kioi, Eriko ^{[3
]}

Chua, Katrin F. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Div Endocrinol Gerontol & Metab, Stanford, CA 94305 USA

[2] VA Palo Alto Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Palo Alto, CA 94304 USA

[3] Daiichi Sankyo Co Ltd, R&D Div, Shinagawa Ku, Tokyo 1408710, Japan

来源：

CELL | 2012年 / 148卷 / 03期

关键词：

SACCHAROMYCES-CEREVISIAE; SIRTUINS; SIRT1;

D O I：

10.1016/j.cell.2012.01.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1 alpha.

引用

页码：387 / 389

页数：3

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