Toward community standards in the quest for orthologs

被引：60

作者：

Dessimoz, Christophe ^{[1
,2
]}

Gabaldon, Toni ^{[3
]}

Roos, David S. ^{[4
,5
]}

Sonnhammer, Erik L. L. ^{[6
]}

Herrero, Javier ^{[7
]}

机构：

[1] ETH, CH-8092 Zurich, Switzerland

[2] Swiss Inst Bioinformat, CH-8092 Zurich, Switzerland

[3] CRG, Bioinformat & Genom Programme, Barcelona 08003, Spain

[4] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[5] Univ Penn, Penn Genome Frontiers Inst, Philadelphia, PA 19104 USA

[6] Stockholm Univ, Stockholm Bioinformat Ctr, Swedish eSci Res Ctr, Dept Biochem & Biophys,Sci Life Lab, SE-17121 Solna, Sweden

[7] Wellcome Trust Genome Campus, European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

BIOINFORMATICS | 2012年 / 28卷 / 06期

基金：

英国惠康基金;

关键词：

GENE; DATABASE; IDENTIFICATION; CONSERVATION; EXPRESSION; PREDICTION; EVOLUTION; RESOURCE;

D O I：

10.1093/bioinformatics/bts050

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

The identification of orthologs-genes pairs descended from a common ancestor through speciation, rather than duplication-has emerged as an essential component of many bioinformatics applications, ranging from the annotation of new genomes to experimental target prioritization. Yet, the development and application of orthology inference methods is hampered by the lack of consensus on source proteomes, file formats and benchmarks. The second 'Quest for Orthologs' meeting brought together stakeholders from various communities to address these challenges. We report on achievements and outcomes of this meeting, focusing on topics of particular relevance to the research community at large. The Quest for Orthologs consortium is an open community that welcomes contributions from all researchers interested in orthology research and applications.

引用

页码：900 / 904

页数：5

共 45 条

[1]

Alexeyenko Andrey, 2006, Drug Discov Today Technol, V3, P137, DOI 10.1016/j.ddtec.2006.06.002

[2]

Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods [J].