The TRAIL of death

被引：12

作者：

Goodwin, RG ^{[1
]}

Smith, CA ^{[1
]}

机构：

[1] Immunex Res & Dev Corp, Seattle, WA 98101 USA

来源：

APOPTOSIS | 1998年 / 3卷 / 02期

关键词：

apoptosis; TNF; TRAIL;

D O I：

10.1023/A:1009640823621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TNF ligand family member termed TRAIL has been shown to induce apoptosis in a wide variety of transformed cell lines. The normal functions of this cytokine in vivo remain, however, relatively unknown. The complexity of this biological system has now increased unexpectedly with the identification of four distinct receptors for TRAIL, two of which have cytoplasmic death domains. This review will describe the known biological effects of TRAIL, as well as the structure and possible functions of its recently identified receptors.

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页码：83 / 88

页数：6

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