A general and versatile synthesis of 2-alkyl-4-aminopyridines

被引：10

作者：

Hegde, VB

Renga, JM

Owen, JM

机构：

[1] Dow AgroSci, Dow Venture Ctr, Discovery Res, Indianapolis, IN 46268 USA

[2] Dow AgroSci, Dow Venture Ctr, Proc Res, Indianapolis, IN 46268 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

aminopyridines; cis-1-methoxy-1-butyn-3-yne; acetylenic ketones;

D O I：

10.1016/S0040-4039(01)00081-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1847 / 1849

页数：3

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