Alarming dendritic cells for Th2 induction

被引：127

作者：

MacDonald, Andrew S. ^{[1
]}

Maizels, Rick M. ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Lab, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1084/jem.20072665

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.

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收藏

页码：13 / 17

页数：5

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