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Anti-kindling effect of slow repetitive transcranial magnetic stimulation in rats

被引：29
作者：
Anschel, DJ
Pascual-Leone, A
Holmes, GL
机构：
[1] Beth Israel Deaconess Med Ctr, Lab Magnet Brain Stimulat, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA
[3] Harvard Univ, Sch Med, Childrens Hosp, Dept Neurol, Boston, MA USA
来源：
NEUROSCIENCE LETTERS | 2003年 / 351卷 / 01期
关键词：
transcranial magnetic stimulation; repetitive transcranial magnetic stimulation; cerebrospinal fluid; endogenous anticonvulsant; kindling;
D O I：
10.1016/S0304-3940(03)00937-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The cerebrospinal fluid (CSF) of animals exposed to electroconvulsive shock (ECS) has anticonvulsant properties when injected into naive animals. The present study investigated whether the CSF of humans exposed to 1 or 10 Hz repetitive transcranial magnetic stimulation (rTMS) has similar properties. Using a 4 day rat flurothyl kindling seizure model we found that the kindling rate was significantly decreased by intraventricular injection of CSF from depressed patients exposed to 1 Hz rTMS. The CSF from patients that underwent 10 Hz rTMS showed a trend toward an increased kindling rate. These results support the similarity of ECS and rTMS and suggest that 1 Hz and 10 Hz rTMS produce distinct physiologic changes. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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页码：9 / 12
页数：4
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