Studies on uracils:: Synthesis of novel uracil analogues via 1,5- and 1,6-intramolecular cycloaddition reactions

被引：4

作者：

Bhuyan, PJ ^{[1
]}

Lekhok, KC ^{[1
]}

Sandhu, JS ^{[1
]}

机构：

[1] Reg Res Lab, Jorhat 785006, Assam, India

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 1998年 / 09期

关键词：

D O I：

10.1039/a800171e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

6-(Tertiary amino)uracils 1 react with dimethyl acetylenedicarboxylate (DMAD) to afford 5.6-dihydropyrrolo[2.3-d]pyrimidines 3a and 3b and the tricyclic analogues 3c-f via 1,5-electrocyclisation in excellent yields, whereas suitably functionalized uracil derivatives 5 undergo intramolecular 1,6-cycloaddition reactions to afford 5.6.7.8-tetahydropyrido[2.3-d] pyrimidines 6a and 6b and the tricyclic analogues 6c-h in high yields.

引用

页码：502 / 503

页数：3

共 25 条

[1] BOTH 2',3'-DIDEOXYTHYMIDINE AND ITS 2',3'-UNSATURATED DERIVATIVE (2',3'-DI-DEOXYTHYMIDINENE) ARE POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION INVITRO [J].