Hypoglycernic effect of Malmea depressa root on streptozotocin diabetic rats

被引：17

作者：

Andrade-Cetto, A ^{[1
]}

Martínez-Zurita, E

Wiedenfeld, H

机构：

[1] Univ Nacl Autonoma Mexico, Fac Ciencias, Dept Biol Celular, Mexico City 04510, DF, Mexico

[2] Univ Bonn, Inst Pharmaceut, D-53121 Bonn, Germany

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 100卷 / 03期

关键词：

Malmea depressa; hypoglycemic effect; streptozotocin-induced diabetic rats; Mexican plants;

D O I：

10.1016/j.jep.2005.03.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycemic effects of water, ethanolic and butanolic extracts prepared from the root of Malmea depressa (Baill) R.E. Fries. (Annonaceae) were studied in diabetic rats (streptozotocin induced). Oral application of water extracts at doses of 40 and 80 mg/kg, ethanolic (112 mg/kg) and butanolic (80 mg/kg) extracts significantly lowered the plasma glucose levels in diabetic rats within three hours. Glibenclamide and metformin were used as references and showed similar hypoglycemic effects like the extracts. The three extracts have a similar chemical composition (HPLC analysis). (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：319 / 322

页数：4

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