Acute severe depression induced by intraoperative stimulation of the substantia nigra: A case report

被引：57

作者：

Blomstedt, Patric ^{[1
]}

Hariz, Marwan I. ^{[1
,2
]}

Lees, Andrew ^{[2
]}

Silberstein, Paul ^{[2
]}

Limousin, Patricia ^{[2
]}

Yelnik, Jerome ^{[3
]}

Agid, Yves

机构：

[1] Univ Hosp No Sweden, Dept Neurosurg, Umea, Sweden

[2] Inst Neurol, London WC1N 3BG, England

[3] Grp Hosp Pitie Salpetriere, INSERM, U289, F-75634 Paris, France

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 03期

关键词：

Parkinson's disease; depression; deep brain stimulation; subthalamic nucleus; substantia nigra;

D O I：

10.1016/j.parkreldis.2007.04.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present a 62 years old man with Parkinson's disease (PD) who underwent bilateral stimulation in the subthalamic nucleus (STN). During the intraoperative evaluation, stimulation through the lowest contact in the right STN area, induced an acute depressive state, during which the patient was crying and expressing that he did not want to live. The patient returned to his normal state of mood within seconds after the cessation of stimulation. Repeated blinded stimulations resulted in the same response. Immediate postoperative magnetic resonance imaging (MRI) revealed that the lowest contact of the right electrode was located in the substantia nigra. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：253 / 256

页数：4

相关论文

共 10 条

[1]

Transient acute depression induced by high-frequency deep-brain stimulation [J].

Bejjani, BP ;

Damier, P ;

Arnulf, I ;

Thivard, L ;

Bonnet, AM ;

Dormont, D ;

Cornu, P ;

Pidoux, B ;

Samson, Y ;

Agid, Y .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (19) :1476-1480

[2]

Depression leading to attempted suicide after bilateral subthalamic nucleus stimulation for Parkinson's disease [J].

Doshi, PK ;

Chhaya, N ;

Bhatt, MH .

MOVEMENT DISORDERS, 2002, 17 (05) :1084-1085

[3]

GOLGI-STUDY OF THE PRIMATE SUBSTANTIA-NIGRA .2. SPATIAL-ORGANIZATION OF DENDRITIC ARBORIZATIONS IN RELATION TO THE CYTOARCHITECTONIC BOUNDARIES AND TO THE STRIATONIGRAL BUNDLE [J].

FRANCOIS, C ;

YELNIK, J ;

PERCHERON, G .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 265 (04) :473-493

[4]

Postoperative management of subthalamic nucleus stimulation for Parkinson's disease [J].

Krack, P ;

Fraix, V ;

Mendes, A ;

Benabid, AL ;

Pollak, P .

MOVEMENT DISORDERS, 2002, 17 :S188-S197

[5]

Mirthful laughter induced by subthalamic nucleus stimulation [J].

Krack, P ;

Kumar, R ;

Ardouin, C ;

Dowsey, PL ;

McVicker, JM ;

Benabid, AL ;

Pollak, P .

MOVEMENT DISORDERS, 2001, 16 (05) :867-875

[6]

Mania following deep brain stimulation for Parkinson's disease [J].

Kulisevsky, J ;

Berthier, ML ;

Gironell, A ;

Pascaul-Sedano, B ;

Molet, J ;

Parés, P .

NEUROLOGY, 2002, 59 (09) :1421-1424

[7]

Kumar R, 1999, NEW ENGL J MED, V341, P1003

[8]

Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation [J].

Kumar, R ;

Lozano, AM ;

Sime, E ;

Halket, E ;

Lang, AE .

NEUROLOGY, 1999, 53 (03) :561-566

[9]

Compulsions, Parkinson's disease, and stimulation [J].

Mallet, L ;

Mesnage, V ;

Houeto, JL ;

Pelissolo, A ;

Yelnik, J ;

Behar, C ;

Gargiulo, M ;

Welter, ML ;

Bonnet, AM ;

Pillon, B ;

Cornu, P ;

Dormont, D ;

Pidoux, B ;

Allilaire, JF ;

Agid, Y .

LANCET, 2002, 360 (9342) :1302-1304

[10]

Transient mania with hypersexuality after surgery for high-frequency stimulation of the subthalamic nucleus in Parkinson's disease [J].

Romito, LM ;

Raja, M ;

Daniele, A ;

Contarino, MF ;

Bentivoglio, AR ;

Barbier, A ;

Scerrati, M ;

Albanese, A .

MOVEMENT DISORDERS, 2002, 17 (06) :1371-1374