The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates

被引：44

作者：

Hommais, F

Gouriou, S

Amorin, C

Bui, H

Rahimy, MC

Picard, B

Denamur, E

机构：

[1] Hop Robert Debre, INSERM U458, F-75019 Paris, France

[2] Hop St Louis, Ctr Etud Polymorphisme, Paris, France

[3] Hop Morvan, Microbiol Lab, Brest, France

[4] Fac Sci Sante, Cotonou, Benin

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 06期

关键词：

D O I：

10.1128/IAI.71.6.3619-3622.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in 132 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.

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页码：3619 / 3622

页数：4

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