The hypoxia-inducible transcription factor (HIF-1 alpha) is a major regulator of energy homeostasis and cellular adaptation to low oxygen stress. Recently, HIF-1 alpha has been discovered to function as a global regulator of macrophage and neutrophil inflammatory and innate immune functions, as befits these specialized phagocytic cells who must operate effectively in the hypoxic microenvironments of infected tissues. This review summarizes current knowledge of the role of HIF-1 alpha in mammalian innate immunity, emphasizing insight gained from conditional gene targeting of the transcription factor in the myeloid cell lineage. Dynamic changes in HIF-1 alpha expression in the course of bacterial, viral, or parasitic infections are outlined and inferences drawn regarding the consequences for pathogen and host. A better understanding of HIF-1 alpha function may provide novel and rational approaches for boosting innate immune function in the therapy of certain complicated infectious disease conditions.
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Yoo, YG
Oh, SH
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Oh, SH
Park, ES
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Park, ES
Cho, H
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Cho, H
Lee, N
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Lee, N
Park, H
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Park, H
Kim, DK
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Kim, DK
Yu, DY
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Yu, DY
Seong, JK
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Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South KoreaSeoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Seong, JK
Lee, MO
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机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Yoo, YG
Oh, SH
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Oh, SH
Park, ES
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Park, ES
Cho, H
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Cho, H
Lee, N
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h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Lee, N
Park, H
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Park, H
Kim, DK
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Kim, DK
Yu, DY
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Yu, DY
Seong, JK
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h-index: 0
机构:
Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South KoreaSeoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea
Seong, JK
Lee, MO
论文数: 0引用数: 0
h-index: 0
机构:Seoul Natl Univ, Coll Vet Med, Lab Dev Biol & Genom, Seoul 150742, South Korea