High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis

被引:199
作者
Cobellis, L
Latini, G
DeFelice, C
Razzi, S
Paris, I
Ruggieri, F
Mazzeo, P
Petraglia, F
机构
[1] Univ Siena, Policlin Le Scotte, Dept Pediat Obstet & Reprod Med, Chair Obstet & Gynecol, I-53100 Siena, Italy
[2] CNR, IFC,Clin Physiol Inst,Perrino Hosp, Div Paediat,Neonatal Intens Care Unit, Lecce Sect, Brindisi, Italy
[3] Univ Siena, Dept Pediat Obstet & Reprod Med, Neonatal Intens Care Unit, I-53100 Siena, Italy
[4] Univ Aquila, Dept Chem Chem Engn & Mat, I-67100 Laquila, Italy
关键词
di-(2-ethylhexyl)-phthalate endometriosis; environmental hazards; mono-ethylhexyl phthalate; plasticizers;
D O I
10.1093/humrep/deg254
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Emerging evidence suggests a potential role for ubiquitous environmental contaminants in the physiopathology of endometriosis. Di-(2-ethylhexyl)-phthalate (DEHP), the most commonly used plasticizer in flexible polyvinylchloride (PVC) formulations, is a widespread environmental contaminant with potentially adverse effects on fertility in animal models. In the present study, we tested the hypothesis that DEHP and/or and its main metabolite, mono-ethylhexyl phthalate (MEHP), play a role in the pathogenesis of endometriosis. METHODS: Specimens of blood and peritoneal fluid were collected in a group of women with endometriosis (n = 55), and in age-matched control women (n = 24). Concentrations of DEHP and MEHP were measured in plasma and peritoneal fluid by using high performance liquid chromatography (HPLC). Differences between groups were tested using the Fisher's exact test, Wilcoxon-test, and Kruskal-Wallis analysis of variance. RESULTS: Endometriotic women showed significantly higher plasma DEHP concentrations than controls (median 0.57 mug/ml, interquartile range: 0.06-1.23; values range: 0-3.24 versus median 0.18 mug/ml, interquartile range: 0-0.44; values range: 0-1.03; P = 0.0047) and 92.6% of them had detectable DEHP and/or MEHP in the peritoneal fluid. No significant differences in either the DEHP/MEHP plasma concentrations (P greater than or equal to 0.31) or DEHP/MEHP peritoneal fluid concentrations (P greater than or equal to 0.66) were observed in the endometriotic patients as a function of the disease stage at the time of diagnosis. CONCLUSIONS: The present findings showed for the first time an association between DEHP plasma concentrations and endometriosis, suggesting a possible role for phthalate esters in the pathogenesis.
引用
收藏
页码:1512 / 1515
页数:4
相关论文
共 34 条
[11]   PHTHALATE ESTER PLASTICIZERS - NEW CLASS OF MARINE POLLUTANT [J].
GIAM, CS ;
CHAN, HS ;
NEFF, GS ;
ATLAS, EL .
SCIENCE, 1978, 199 (4327) :419-421
[12]  
GRIFFITHS WC, 1985, ANN CLIN LAB SCI, V15, P140
[13]  
*HLTH CAN EXP ADV, 2002, FIN REP 2002 JAN 11
[14]   Reproductive toxicology: current and future directions [J].
Hoyer, PB .
BIOCHEMICAL PHARMACOLOGY, 2001, 62 (12) :1557-1564
[15]   Inhibition of oocyte development in Japanese medaka (Oryzias latipes) exposed to di-2-ethylhexyl phthalate [J].
Kim, EJ ;
Kim, JW ;
Lee, SK .
ENVIRONMENT INTERNATIONAL, 2002, 28 (05) :359-365
[16]   REPRODUCTIVE EFFECTS OF 4 PHTHALIC-ACID ESTERS IN THE MOUSE [J].
LAMB, JC ;
CHAPIN, RE ;
TEAGUE, J ;
LAWTON, AD ;
REEL, JR .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 88 (02) :255-269
[17]   STEROIDOGENIC ASSESSMENT USING OVARY CULTURE IN CYCLING RATS - EFFECTS OF BIS(2-DIETHYLHEXYL) PHTHALATE ON OVARIAN-STEROID PRODUCTION [J].
LASKEY, JW ;
BERMAN, E .
REPRODUCTIVE TOXICOLOGY, 1993, 7 (01) :25-33
[18]   Materials degradation in endotracheal tubes: a potential contributor to bronchopulmonary dysplasia [J].
Latini, G ;
Avery, GB .
ACTA PAEDIATRICA, 1999, 88 (10) :1174-1175
[19]   Potential hazards of exposure to di-(2-ethylhexyl)-phthalate in babies [J].
Latini, G .
BIOLOGY OF THE NEONATE, 2000, 78 (04) :269-276
[20]   Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats [J].
Li, LH ;
Jester, WF ;
Orth, JM .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1998, 153 (02) :258-265