Research into the therapeutic roles of two-pore-domain potassium channels

被引:42
作者
Es-Salah-Lamoureux, Zeineb [1 ]
Steele, David F. [1 ]
Fedida, David [1 ]
机构
[1] Univ British Columbia, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC V5Z 1M9, Canada
基金
加拿大健康研究院;
关键词
POLYUNSATURATED FATTY-ACIDS; BACKGROUND K-2P CHANNELS; DOMAIN K+ CHANNELS; ENTORHINAL CORTEX; NEURONAL EXCITABILITY; GENE-EXPRESSION; TASK CHANNELS; TREK-1; ACTIVATION; CURRENTS;
D O I
10.1016/j.tips.2010.09.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The K-2P potassium channels are responsible for the background conductance observed in several tissues. Their ubiquitous localization and thus their potential implications in diseases have led to increased research on these channels over the last few years. In this review, we outline different aspects of the research on K-2P channels and highlight some of the latest discoveries in this area. We focus on research into K-2P channels as potential therapeutic targets in ischemia/hypoxia, depression, memory disorders, pain, cardiovascular disease and disorders of the immune system. We address the challenge of developing novel pharmacological compounds to target these channels. We also discuss the regulation of expression of the K-2P gene in health and disease, as well as the value of assessing the expression of K-2P channels as potential biomarkers of disease.
引用
收藏
页码:587 / 595
页数:9
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