Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

被引：126

作者：

Clark, Brian S. ^{[1
]}

Blackshaw, Seth ^{[1
,2
,3
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Solomon Snyder Dept Neurosci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Ctr High Throughput Biol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA

来源：

FRONTIERS IN GENETICS | 2014年 / 5卷

关键词：

NATURAL ANTISENSE TRANSCRIPTS; EPIGENETIC REGULATION; HUMAN GENOME; HUMAN QKI; GENE; EXPRESSION; CHROMATIN; POLYCOMB; IDENTIFICATION; PLURIPOTENCY;

D O I：

10.3389/fgene.2014.00164

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Comprehensive analysis of the mammalian transcriptome has revealed that long noncoding RNAs (IncRNAs) may make up a large fraction of cellular transcripts. Recent years have seen a surge of studies aimed at functionally characterizing the role of IncRNAs in development and disease. In this review, we discuss new findings implicating IncRNAs in controlling development of the central nervous system (CNS). The evolution of the higher vertebrate brain has been accompanied by an increase in the levels and complexities of IncRNAs expressed within the developing nervous system. Although a limited number of CNS-expressed IncRNAs are now known to modulate the activity of proteins important for neuronal differentiation, the function of the vast majority of neuronal-expressed IncRNAs is still unknown. Topics of intense current interest include the mechanism by which CNS-expressed IncRNAs might function in epigenetic and transcriptional regulation during neuronal development, and how gain and loss of function of individual IncRNAs contribute to neurological diseases.

引用

页数：19

共 202 条

[1]

Human QKI, a new candidate gene for schizophrenia involved in myelination [J].

Åberg, K ;

Saetre, P ;

Lindholm, E ;

Ekhohn, B ;

Pettersson, U ;

Adolfsson, R ;

Jazin, E .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (01) :84-90

[2]

Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia [J].

Aberg, Karolina ;

Saetre, Peter ;

Jareborg, Niclas ;

Jazin, Elena .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (19) :7482-7487

[3]

REST and CoREST Modulate Neuronal Subtype Specification, Maturation and Maintenance [J].

Abrajano, Joseph J. ;

Qureshi, Irfan A. ;

Gokhan, Solen ;

Zheng, Deyou ;

Bergman, Aviv ;

Mehler, Mark F. .

PLOS ONE, 2009, 4 (12)

[4]

β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [J].

Abramov, AY ;

Canevari, L ;

Duchen, MR .

JOURNAL OF NEUROSCIENCE, 2004, 24 (02) :565-575

[5]

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression [J].

Aguilo, Francesca ;

Zhou, Ming-Ming ;

Walsh, Martin J. .

CANCER RESEARCH, 2011, 71 (16) :5365-5369

[6]

Identification of Novel GDNF Isoforms and cis-Antisense GDNFOS Gene and Their Regulation in Human Middle Temporal Gyrus of Alzheimer Disease [J].

Airavaara, Mikko ;

Pletnikova, Olga ;

Doyle, Maire E. ;

Zhang, Yong E. ;

Troncoso, Juan C. ;

Liu, Qing-Rong .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (52) :45093-45102

[7]

Natural antisense transcripts associated with genes involved in eye development [J].

Alfano, G ;

Vitiello, C ;

Caccioppoli, C ;

Caramico, T ;

Carola, A ;

Szego, MJ ;

McInnes, RR ;

Auricchio, A ;

Banfi, S .

HUMAN MOLECULAR GENETICS, 2005, 14 (07) :913-923

[8]

GDNF, NGF and BDNF as therapeutic options for neurodegeneration [J].

Allen, Shelley J. ;

Watson, Judy J. ;

Shoemark, Deborah K. ;

Barua, Neil U. ;

Patel, Nikunj K. .

PHARMACOLOGY & THERAPEUTICS, 2013, 138 (02) :155-175

[9]

ALTSHULER D, 1993, DEVELOPMENT, V119, P1317

[10]

The eukaryotic genome as an RNA machine [J].

Amaral, Paulo P. ;

Dinger, Marcel E. ;

Mercer, Tim R. ;

Mattick, John S. .

SCIENCE, 2008, 319 (5871) :1787-1789

← 1 2 3 4 5 6 7 8 9 10 →