The origin of the genetic code: theories and their relationships, a review

被引:105
作者
Di Giulio, M [1 ]
机构
[1] CNR, Inst Genet & Biophys Adriano Buzzati Traverso, I-80125 Naples, Italy
关键词
genetic code theories; coevolution; stereochemistry; error-minimization hypothesis; codon plurality; molecular weight of amino acids;
D O I
10.1016/j.biosystems.2004.11.005
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A review of the main theories proposed to explain the origin of the genetic code is presented. I analyze arguments and data in favour of different theories proposed to explain the origin of the organization of the genetic code. It is possible to suggest a mechanism that makes compatible the different theories of the origin of the code, even if these are based on a historical or physicochemical determinism and thus appear incompatible by definition. Finally, I discuss the question of why a given number of synonymous codons was attributed to the amino acids in the genetic code. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:175 / 184
页数:10
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