Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy

被引：155

作者：

Brule, Severine ^{[1
,2
]}

Levy, Michael ^{[3
]}

Wilhelm, Claire ^{[3
]}

Letourneur, Didier ^{[1
]}

Gazeau, Florence ^{[3
]}

Menager, Christine ^{[2
]}

Le Visage, Catherine ^{[1
]}

机构：

[1] CHU Xavier Bichat, INSERM, U698, F-75877 Paris 18, France

[2] Univ Paris 06, CNRS, ESPCI Lab, PECSA UMR 7195, F-75252 Paris 05, France

[3] Univ Paris Diderot, CNRS, UMR7057, Lab MSC, F-75205 Paris 13, France

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 06期

关键词：

FERRIMAGNETIC PARTICLES; PHYSICAL EVALUATION; HYPERTHERMIA; MICROPARTICLES; NANOPARTICLES; REMOVAL; LIQUIDS; FLUIDS;

D O I：

10.1002/adma.201003763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alginate microbeads with iron oxide nanoparticle heaters that carry doxorubicin are investigated in vitro for simultaneous drug targeting and local heat generation (hyperthermia). Application of an alternative magnetic field (AMF) causes magnetic-hyperthermia-enhanced doxorubicin release. The AMF-triggered drug release and hyperthermia exhibit synergistic effects and result in significant tumor cell death.

引用

页码：787 / +

页数：5

共 28 条

[1] MAGNETIC COLLOIDAL PROPERTIES OF IONIC FERROFLUIDS [J].

BACRI, JC ;

PERZYNSKI, R ;

SALIN, D ;

CABUIL, V ;

MASSART, R .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1986, 62 (01) :36-46

[2] A bi-modal approach against cancer: Magnetic alginate nanoparticles for combined chemotherapy and hyperthermia [J].

Ciofani, Gianni ;

Riggio, Cristina ;

Raffa, Vittoria ;

Menciassi, Arianna ;

Cuschieri, Alfred .

MEDICAL HYPOTHESES, 2009, 73 (01) :80-82

[3] Alginate microparticles for enzyme peroral administration [J].

Coppi, G ;

Iannuccelli, V ;

Bernabei, MT ;

Cameroni, R .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 242 (1-2) :263-266

[4]

Douziech-Eyrolles L, 2007, INT J NANOMED, V2, P541

[5] Towards a versatile platform based on magnetic nanoparticles for in vivo applications [J].

Duguet, E. ;

Vasseur, S. ;

Mornet, S. ;

Goglio, G. ;

Demourgues, A. ;

Portier, J. ;

Grasset, F. ;

Veverka, P. ;

Pollert, E. .

BULLETIN OF MATERIALS SCIENCE, 2006, 29 (06) :581-586

[6] Synthesis of aqueous magnetic liquids by surface complexation of maghemite nanoparticles [J].

Fauconnier, N ;

Bée, A ;

Roger, J ;

Pons, JN .

JOURNAL OF MOLECULAR LIQUIDS, 1999, 83 (1-3) :233-242

[7] Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia [J].

Fortin, Jean-Paul ;

Wilhelm, Claire ;

Servais, Jacques ;

Menager, Christine ;

Bacri, Jean-Claude ;

Gazeau, Florence .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2628-2635

[8] Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan - a review [J].

George, Meera ;

Abraham, T. Emilia .

JOURNAL OF CONTROLLED RELEASE, 2006, 114 (01) :1-14

[9]

Gibbs BF, 1999, INT J FOOD SCI NUTR, V50, P213, DOI 10.1080/096374899101256

[10] Nanocomposite Degradable Hydrogels: Demonstration of Remote Controlled Degradation and Drug Release [J].

Hawkins, Ashley M. ;

Satarkar, Nitin S. ;

Hilt, J. Zach .

PHARMACEUTICAL RESEARCH, 2009, 26 (03) :667-673

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