α-helical polypeptide microcapsules formed by emulsion-templated self-assembly

被引：37

作者：

Morikawa, M

Yoshihara, M

Endo, T

Kimizuka, N ^{[1
]}

机构：

[1] Kyushu Univ, Dept Chem & Biochem, Grad Sch Engn, Fukuoka 8128581, Japan

[2] Kinki Univ, Henkel Res Ctr Adv Technol, Mol Engn Inst, Fukuoka 8208555, Japan

[3] Kinki Univ, Sch Sci & Engn, Dept Appl Chem, Higashiosaka, Osaka 5778502, Japan

[4] Yamagata Univ, Fac Engn, Dept Polymer Sci & Engn, Yonezawa, Yamagata 9928510, Japan

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 05期

关键词：

amphiphiles; emulsion microcapsules; polypeptides; self-assembly;

D O I：

10.1002/chem.200400751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-Helical peptide microcapsules were prepared by the emulsion-templated self-assembly of amphiphilic poly(gamma-benzyl L-glutamate)s (PBLG) 1. By mixing solutions of 1 in dichloromethane (in the form of a sodium salt) with water, oil-in-water emulsions were obtained. Spontaneous stripping of the dichloromethane phase caused a decrease in the diameter of the microdroplets and finally stable microcapsules formed. The microcapsules contain an inner aqueous phase as observed by confocal laser scanning microscopy (CLSM). Binding of hydrophobic pyrene molecules to the polypeptide shell was also demonstrated. The present polypeptide microcapsules are stable even after drying in air and they would serve as supramolecular vehicles for both hydrophobic and water-soluble molecules.

引用

页码：1574 / 1578

页数：5

共 41 条

[1] Responsive gels formed by the spontaneous self-assembly of peptides into polymeric beta-sheet tapes [J].