Self-assembly of Aβ(10-35)-PEG block copolymer fibrils

被引：116

作者：

Burkoth, TS

Benzinger, TLS

Urban, V

Lynn, DG

Meredith, SC

Thiyagarajan, P

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[3] Argonne Natl Lab, Intense Pulse Neutron Source, Argonne, IL 60439 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 32期

关键词：

D O I：

10.1021/ja991233x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：7429 / 7430

页数：2

共 21 条

[1] Propagating structure of Alzheimer's β-amyloid(10-35) is parallel β-sheet with residues in exact register [J].

Benzinger, TLS ;

Gregory, DM ;

Burkoth, TS ;

Miller-Auer, H ;

Lynn, DG ;

Botto, RE ;

Meredith, SC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13407-13412

[2] Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous beta-sheet helix [J].

Blake, C ;

Serpell, L .

STRUCTURE, 1996, 4 (08) :989-998

[3] C-terminal PEG blocks the irreversible step in β-amyloid(10-35) fibrillogenesis [J].

Burkoth, TS ;

Benzinger, TLS ;

Jones, DNM ;

Hallenga, K ;

Meredith, SC ;

Lynn, DG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (30) :7655-7656

[4]

BURKOTH TS, UNPUB

[5] In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics [J].

Esler, WP ;

Stimson, ER ;

Ghilardi, JR ;

Vinters, HV ;

Lee, JP ;

Mantyh, PW ;

Maggio, JE .

BIOCHEMISTRY, 1996, 35 (03) :749-757

[6] Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence [J].

Esler, WP ;

Stimson, ER ;

Ghilardi, JR ;

Lu, YA ;

Felix, AM ;

Vinters, HV ;

Mantyh, PW ;

Lee, JP ;

Maggio, JE .

BIOCHEMISTRY, 1996, 35 (44) :13914-13921

[7] STRUCTURAL MODEL FOR THE BETA-AMYLOID FIBRIL BASED ON INTERSTRAND ALIGNMENT OF AN ANTIPARALLEL-SHEET COMPRISING A C-TERMINAL PEPTIDE [J].

LANSBURY, PT ;

COSTA, PR ;

GRIFFITHS, JM ;

SIMON, EJ ;

AUGER, M ;

HALVERSON, KJ ;

KOCISKO, DA ;

HENDSCH, ZS ;

ASHBURN, TT ;

SPENCER, RGS ;

TIDOR, B ;

GRIFFIN, RG .

NATURE STRUCTURAL BIOLOGY, 1995, 2 (11) :990-998

[8] Amyloid fibrils may be assembled from β-helical protofibrils [J].

Lazo, ND ;

Downing, DT .

BIOCHEMISTRY, 1998, 37 (07) :1731-1735

[9] Structural analysis of Alzheimer's β(1-40) amyloid:: Protofilament assembly of tubular fibrils [J].

Malinchik, SB ;

Inouye, H ;

Szumowski, KE ;

Kirschner, DA .

BIOPHYSICAL JOURNAL, 1998, 74 (01) :537-545

[10] Context-dependent secondary structure formation of a designed protein sequence [J].

Minor, DL ;

Kim, PS .

NATURE, 1996, 380 (6576) :730-734

← 1 2 3 →