Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

被引:226
作者
De Palma, Michele [1 ,2 ]
Murdoch, Craig [3 ]
Venneri, Mary Anna [1 ,2 ]
Naldin, Luigi [1 ,2 ,4 ]
Lewis, Claire E.
机构
[1] Ist Sci San Raffaele, Angiogenesis & Tumor Targeting Res Unit, I-20132 Milan, Italy
[2] Ist Sci San Raffaele, San Raffaele Telethon Inst Gene Therapy, I-20132 Milan, Italy
[3] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Surg, Sheffield S10 2TA, S Yorkshire, England
[4] San Raffaele Vita Salute Univ, I-20132 Milan, Italy
关键词
D O I
10.1016/j.it.2007.09.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor-infiltrating myeloid cells are involved in crucial processes during tumor development. A subset of monocytes that express the angiopoietin receptor Tie2 play an important role in tumor angiogenesis. Selective depletion of these Tie2-expressing monocytes (TEMs) in tumor-bearing mice inhibits tumor angiogenesis and growth, suggesting that they might regulate angiogenic processes in tumors by providing paracrine support to nascent blood vessels. TEMs have also been identified in human blood and tumors. We discuss here the therapeutic opportunities emanating from the discovery of TEMs, which include the identification of new antitumor targets, monitoring TEMs as surrogate markers for clinical responses in cancer patients, and the possible use of TEMs as cellular vehicles for gene delivery to tumors.
引用
收藏
页码:519 / 524
页数:6
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