Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking

被引:93
作者
d'Herbomez, Michele [1 ]
Caron, Philippe [1 ]
Bauters, Catherine [2 ]
Do Cao, Christine [2 ]
Schlienger, Jean-Louis [3 ]
Sapin, Remy [4 ]
Baldet, Line [5 ]
Carnaille, Bruno [6 ]
Wemeau, Jean-Louis [2 ]
机构
[1] CHU Rangueil, Dept Endocrinol & Metab Dis, Toulouse, France
[2] CHRU, Clin Endocrinol, Lille, France
[3] Hop Hautepierre, Serv Med Interne, Strasbourg, France
[4] Inst Biol Phys, Strasbourg, France
[5] CHU, Clin Endocrinol, Montpellier, France
[6] CHRU, Dept Endocrine Surg, Lille, France
关键词
D O I
10.1530/EJE-07-0566
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The objective of this study was to re-evaluate the adult C-T reference values determined by five different immunoassays and by introducing criteria for selecting control subjects. Design: A prospective multicenter study. Patients: Three hundred and seventy-five clinically euthyroid subjects. Methods: We used five different C-T immunoassays. Sera were assayed for the concentration of TSH, gastrin, procalcitonin, urea, calcium, and anti-thyroperoxidase antibodies. Results: Screening for the various potential causes of hypercalcitoninemia led to the exclusion of 23%, of the sera. Our reference value analysis dealt with 287 subjects (142 men and 145 women). The proportion of samples in which no C-T was detected varied from 56% (for assay D) to 88% (for assay C). We observed significant correlations (whose magnitude depended on the assay used) between G,. levels and age or body mass index (BMI) (primarily in men). The distribution of C-T. levels showed that 4.7, 9.8, 2.5, 6.5, and 8.0% of the values were over 10 pg/ml respectively. These values corresponded essentially to samples from 11 male subjects (median age: 55 years), most of whom were smokers. The highest C-T. values were around twice as high in men than women, and were higher in smokers than non-smokers. Conclusion: In clinical practice (and after having excluded the usual causes of raised C-T levels), the interpretation of C-T assay results must take into account i) the method used; ii) the patient's gender, age, and weight; and iii) the potential influence of cigarette smoking.
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收藏
页码:749 / 755
页数:7
相关论文
共 41 条
[21]   Pentagastrin testing in patients with renal insufficiency: Normal responsivity of mature calcitonin [J].
Lissak, B ;
Baudin, E ;
Cohen, R ;
Barbot, N ;
Meyrier, A ;
Niccoli, P ;
Bouyge, N ;
Modigliani, E .
THYROID, 1998, 8 (03) :265-268
[22]   ABNORMAL CALCITONIN BASAL LEVELS AND PENTAGASTRIN RESPONSE IN PATIENTS WITH CHRONIC-RENAL-FAILURE ON MAINTENANCE HEMODIALYSIS [J].
NICCOLI, P ;
BRUNET, P ;
ROUBICEK, C ;
ROUX, F ;
BAUDIN, E ;
LEJEUNE, PJ ;
BERLAND, Y ;
CONTEDEVOLX, B .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 132 (01) :75-81
[23]   Interest of routine measurement of serum calcitonin: Study in a large series of thyroidectomized patients [J].
Niccoli, P ;
WionBarbot, N ;
Caron, P ;
Henry, JF ;
DeMicco, C ;
SaintAndre, JP ;
Bigorne, JC ;
Modigliani, E ;
ContDevolx, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (02) :338-341
[24]  
Niccoli P, 1996, ANN ENDOCRINOL-PARIS, V57, P15
[25]   ROUTINE MEASUREMENT OF SERUM CALCITONIN IN NODULAR THYROID-DISEASES ALLOWS THE PREOPERATIVE DIAGNOSIS OF UNSUSPECTED SPORADIC MEDULLARY-THYROID CARCINOMA [J].
PACINI, F ;
FONTANELLI, M ;
FUGAZZOLA, L ;
ELISEI, R ;
ROMEI, C ;
DICOSCIO, G ;
MICCOLI, P ;
PINCHERA, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (04) :826-829
[26]   Calcitonin levels are similar in goitrous euthyroid patients with or without thyroid antibodies, as well as in hypothyroid patients [J].
Pantazi, H ;
Papapetrou, PD .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1998, 138 (05) :530-535
[27]   Heterophilic antibodies causing falsely high serum calcitonin values [J].
Papapetrou, P. D. ;
Polymeris, A. ;
Karga, H. ;
Vaiopoulos, G. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2006, 29 (10) :919-923
[28]   The environment and autoimmune thyroid diseases [J].
Prummel, MF ;
Strieder, T ;
Wiersinga, WM .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 150 (05) :605-618
[29]   PREVALENCE OF SPORADIC MEDULLARY-THYROID CARCINOMA - THE IMPORTANCE OF ROUTINE MEASUREMENT OF SERUM CALCITONIN IN THE DIAGNOSTIC EVALUATION OF THYROID-NODULES [J].
RIEU, M ;
LAME, MC ;
RICHARD, A ;
LISSAK, B ;
SAMBORT, B ;
VUONGNGOC, P ;
BERROD, JL ;
FOMBEUR, JP .
CLINICAL ENDOCRINOLOGY, 1995, 42 (05) :453-460
[30]   Is medullary thyroid cancer predictable?: A prospective study of 86 patients with abnormal pentagastrin tests [J].
Scheuba, C ;
Kaserer, K ;
Weinhäusl, A ;
Pandev, R ;
Kaider, A ;
Passler, C ;
Prager, G ;
Vierhapper, H ;
Haas, OA ;
Niederle, B .
SURGERY, 1999, 126 (06) :1089-1095