New synthetic tools for peptide-tetraphenylporphyrin derivatives

被引：3

作者：

De Luca, S

Bruno, G

Fattorusso, R

Isernia, C

Pedone, C

Morelli, G

机构：

[1] CNR, Ctr Interuniv Ricerca Peptidi Bioattivi, I-80134 Naples, Italy

[2] CNR, Ctr Studio Biocristallog, I-80134 Naples, Italy

[3] Univ Naples 2, Dipartimento Sci Ambientali, I-81100 Caserta, Italy

来源：

LETTERS IN PEPTIDE SCIENCE | 1998年 / 5卷 / 04期

关键词：

metalloenzymes; peptide-porphyrins; solid-phase peptide-synthesis;

D O I：

10.1023/A:1008869818565

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New metal-tetraphenylporphyrins and Fmoc-lysine-metalloporphyrin derivatives have been used to prepare peptide-porphyrin and peptide-metalloporphyrin compounds via solid-phase peptide synthesis. A water-soluble peptide, covalently bound to a manganese(III)-porphyrin, has been used as a catalyst to promote the oxidation of ABTS by hydrogen peroxide or t-butylhydroperoxide.

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收藏

页码：269 / 276

页数：8

相关论文

共 16 条

[1] THE PEROXIDASIC ACTIVITY OF THE HEME OCTAPEPTIDE MICROPEROXIDASE-8 (MP-8) - THE KINETIC MECHANISM OF THE CATALYTIC REDUCTION OF H2O2 BY MP-8 USING 2,2'-AZINOBIS-(3-ETHYLBENZOTHIAZOLINE-6-SULFONATE) (ABTS) AS REDUCING SUBSTRATE [J].

ADAMS, PA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1990, (08) :1407-1414

[2] OXYGEN ACTIVATION AND LIGAND-BINDING BY PURE HEME-OCTAPEPTIDE MICROPEROXIDASE-8 (MP-8) [J].

ADAMS, PA ;

BYFIELD, MP ;

MILTON, RCD ;

PRATT, JM .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1988, 34 (03) :167-175

[3]

Buchler J. W., 1978, PORPHYRINS, V1, P389

[4] DESIGN OF A HEME-BINDING 4-HELIX BUNDLE [J].

CHOMA, CT ;

LEAR, JD ;

NELSON, MJ ;

DUTTON, PL ;

ROBERTSON, DE ;

DEGRADO, WF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (03) :856-865

[5]

COLGLOUGH N, 1995, J CHEM SOC P1, P235

[6] HYDROXYLATION AND EPOXIDATION CATALYZED BY IRON-PORPHINE COMPLEXES - OXYGEN-TRANSFER FROM IODOSYLBENZENE [J].

GROVES, JT ;

NEMO, TE ;

MYERS, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (04) :1032-1033

[7] ELECTRON PATHWAYS IN CATALASE AND PEROXIDASE ENZYMIC CATALYSIS - METAL AND MACROCYCLE OXIDATIONS OF IRON PORPHYRINS AND CHLORINS [J].

HANSON, LK ;

CHANG, CK ;

DAVIS, MS ;

FAJER, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (03) :663-670

[8] INVESTIGATION OF THE SYNTHESIS OF ORTHO-SUBSTITUTED TETRAPHENYLPORPHYRINS [J].

LINDSEY, JS ;

WAGNER, RW .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (04) :828-836

[9] SULFIDE OXIDATION, AMINE N-DEMETHYLATION, AND OLEFIN OXIDATION BY HEME-UNDECAPEPTIDE, MICROPEROXIDASE-11, IN THE PRESENCE OF HYDROGEN-PEROXIDE [J].

MASHINO, T ;

NAKAMURA, S ;

HIROBE, M .

TETRAHEDRON LETTERS, 1990, 31 (22) :3163-3166

[10] MONOFUNCTIONAL ELECTROPHILIC AND NUCLEOPHILIC DERIVATIVES OF MESO-TETRAPHENYLPORPHYRIN FOR ATTACHMENT TO PEPTIDES [J].

MATTHEWS, SE ;

POUTON, CW ;

THREADGILL, MD .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (17) :1809-1811