The use of mouse models to understand and improve cognitive deficits in Down syndrome

被引：80

作者：

Das, Ishita ^{[1
]}

Reeves, Roger H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Physiol & McKusick Nathans, Inst Med Genet, Sch Med, Baltimore, MD 21205 USA

来源：

DISEASE MODELS & MECHANISMS | 2011年 / 4卷 / 05期

关键词：

LONG-TERM POTENTIATION; MORRIS WATER MAZE; TS65DN MOUSE; SYNAPTIC PLASTICITY; RECOGNITION MEMORY; CRITICAL REGION; CONTEXT DISCRIMINATION; ALZHEIMERS-DISEASE; ANIMAL-MODEL; RAT-BRAIN;

D O I：

10.1242/dmm.007716

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Remarkable advances have been made in recent years towards therapeutics for cognitive impairment in individuals with Down syndrome (DS) by using mouse models. In this review, we briefly describe the phenotypes of mouse models that represent outcome targets for drug testing, the behavioral tests used to assess impairments in cognition and the known mechanisms of action of several drugs that are being used in preclinical studies or are likely to be tested in clinical trials. Overlaps in the distribution of targets and in the pathways that are affected by these diverse drugs in the trisomic brain suggest new avenues for DS research and drug development.

引用

页码：596 / 606

页数：11

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