In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test

被引：89

作者：

Gebel, T ^{[1
]}

Kevekordes, S ^{[1
]}

Pav, K ^{[1
]}

Edenharder, R ^{[1
]}

Dunkelberg, H ^{[1
]}

机构：

[1] UNIV MAINZ,DEPT HYG,INST MED MICROBIOL & HYG,D-55131 MAINZ,GERMANY

来源：

ARCHIVES OF TOXICOLOGY | 1997年 / 71卷 / 03期

关键词：

mouse bone-marrow micronucleus test; herbicides; atrazine; trifluraline;

D O I：

10.1007/s002040050375

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The herbicides alachlor, atrazine, terbuthylazine, gluphosinate-ammonium, isoproturon, pendimethaline and trifluralin were tested for genotoxicity in the mouse bone-marrow micronucleus test (MNT). Both atrazine and trifluraline caused a significant increase in the number of micronuclei at doses of 1400 mg/kg body weight in female mice only. Alachlor, terbuthylazine, gluphosinate-ammonium, isoproturon and pendimethaline did not have any genotoxic effect in the mouse bone-marrow micronucleus test in either female or male animals.

引用

页码：193 / 197

页数：5