A model for bilayer membrane electroporation based on resultant electromechanical stress

被引：46

作者：

Lewis, TJ ^{[1
]}

机构：

[1] Univ Wales, Sch Informat, Bangor LL57 1UT, Gwynedd, Wales

来源：

IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION | 2003年 / 10卷 / 05期

关键词：

phospholipid bilayers; membrane potential; electroporation; electromechanical forces; Helmholtz equation; membrane tension; Lippmann effect;

D O I：

10.1109/TDEI.2003.1237326

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Reconsideration of the effect of an electrical field applied across a phospholipid bilayer membrane shows that, in addition to a compressive stress normal to the membrane plane, transverse traction stresses are generated in the lateral plane of the membrane. In the fields usually employed for electroporation these transverse stresses are likely to be sufficient to reduce the membrane tension considerably, causing electroporation and rupture. This mode of field-induced change in the membrane provides a natural model for the various forms of electroporation.

引用

页码：769 / 777

页数：9

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