The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

被引：7432

作者：

Arber, Daniel A. ^{[1
]}

Orazi, Attilio ^{[2
]}

Hasserjian, Robert ^{[3
]}

Thiele, Jurgen ^{[4
]}

Borowitz, Michael J. ^{[5
]}

Le Beau, Michelle M. ^{[6
]}

Bloomfield, Clara D. ^{[7
,8
]}

Cazzola, Mario ^{[9
,10
]}

Vardiman, James W. ^{[11
]}

机构：

[1] Stanford Univ, Dept Pathol, 300 Pasteur Dr H1401 M-C 5627, Stanford, CA 94305 USA

[2] Weill Cornell Med Coll, Dept Pathol, New York, NY USA

[3] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[4] Univ Cologne, Inst Pathol, Joseph Stelzmann Str 9, Cologne, Germany

[5] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[6] Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA

[7] Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA

[8] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA

[9] Univ Pavia, Dept Mol Med, Via Palestro 3, I-27100 Pavia, Italy

[10] Fdn IRCCS Policlin San Matteo, Dept Hematol Oncol, Pavia, Italy

[11] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

来源：

BLOOD | 2016年 / 127卷 / 20期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; SINGLE CEBPA MUTATIONS; CHRONIC MYELOMONOCYTIC LEUKEMIA; INTERMEDIATE-RISK CYTOGENETICS; MYELODYSPLASTIC SYNDROMES MDS; ACUTE ERYTHROID LEUKEMIA; PHENOTYPE ACUTE-LEUKEMIA; ESSENTIAL THROMBOCYTHEMIA; MULTILINEAGE DYSPLASIA; CLONAL HEMATOPOIESIS;

D O I：

10.1182/blood-2016-03-643544

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues was last updated in 2008. Since then, there have been numerous advances in the identification of unique biomarkers associated with some myeloid neoplasms and acute leukemias, largely derived from gene expression analysis and next-generation sequencing that can significantly improve the diagnostic criteria as well as the prognostic relevance of entities currently included in the WHO classification and that also suggest new entities that should be added. Therefore, there is a clear need for a revision to the current classification. The revisions to the categories of myeloid neoplasms and acute leukemia will be published in a monograph in 2016 and reflect a consensus of opinion of hematopathologists, hematologists, oncologists, and geneticists. The 2016 edition represents a revision of the prior classification rather than an entirely new classification and attempts to incorporate new clinical, prognostic, morphologic, immunophenotypic, and genetic data that have emerged since the last edition. The major changes in the classification and their rationale are presented here.

引用

页码：2391 / 2405

页数：15

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