Cytoskeletal dynamics and transport in growth cone motility and axon guidance

被引：717

作者：

Dent, EW ^{[1
]}

Gertler, FB ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

NEURON | 2003年 / 40卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(03)00633-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of many signaling cascades that influence the developing neuron. Regulation of polymer dynamics and transport are crucial for the proper growth cone motility. This review addresses how actin filaments, microtubules, and their associated proteins play crucial roles in growth cone motility, axon outgrowth, and guidance. We present a working model for cytoskeletal regulation of directed axon outgrowth. An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation.

引用

收藏

页码：209 / 227

页数：19

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