The NLRP3 Inflammasome and Its Role in Sepsis Development

被引：263

作者：

Danielski, Lucineia Gainski ^{[1
]}

Giustina, Amanda Della ^{[1
]}

Bonfante, Sandra ^{[1
]}

Barichello, Tatiana ^{[2
,3
]}

Petronilho, Fabricia ^{[1
]}

机构：

[1] Univ South Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Lab Neurobiol Inflammatory & Metab Proc, Tubarao, SC, Brazil

[2] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Lab Expt Microbiol, Criciuma, SC, Brazil

[3] Univ Texas Hlth Sci Ctr Houston, Med Sch, Dept Psychiat & Behav Sci, Ctr Expt Models Psychiat, Houston, TX 77030 USA

来源：

INFLAMMATION | 2020年 / 43卷 / 01期

关键词：

sepsis; NLRP3; inflammasome; organ failure; TOLL-LIKE; ACTIVATION; LPS; MECHANISM; MITOCHONDRIA; MITOPHAGY; PROTECTS; SURVIVAL; INJURY; SIGNAL;

D O I：

10.1007/s10753-019-01124-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Abstract The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1 beta and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

引用

收藏

页码：24 / 31

页数：8

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