Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines

被引：85

作者：

Marrison, LR

Dickinson, JM

Fairlamb, IJS

机构：

[1] Manchester Metropolitan Univ, Dept Chem & Mat, Manchester M1 5GD, Lancs, England

[2] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(02)00824-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon-carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines show that 4-alkynyl-6-methyl-2-pyrones have excellent potential as anticancer agents. The pyrones demonstrate broad spectrum antimicrobial activities. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3509 / 3513

页数：5

共 30 条

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