Potent antimitotic and cell growth inhibitory properties of substituted chalcones

被引：359

作者：

Ducki, S

Forrest, R

Hadfield, JA

Kendall, A

Lawrence, NJ

McGown, AT

Rennison, D

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs, England

[2] Christie Hosp NHS Trust, Paterson Inst Canc Res, CRC, Dept Drug Dev, Manchester M20 4BX, Lancs, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 09期

关键词：

antitumour compounds; chalcones; molecular modelling/mechanics; X-ray crystal structures;

D O I：

10.1016/S0960-894X(98)00162-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'-trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1056

页数：6

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