Gait Analysis in Normal and Spinal Contused Mice Using the TreadScan System
被引:75
作者:
Beare, Jason E.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Beare, Jason E.
[1
,2
]
Morehouse, Johnny R.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Morehouse, Johnny R.
[1
,3
]
DeVries, William H.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
DeVries, William H.
[1
,3
]
Enzmann, Gaby U.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Enzmann, Gaby U.
[1
,3
]
Burke, Darlene A.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Burke, Darlene A.
[1
,3
]
Magnuson, David S. K.
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机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Magnuson, David S. K.
[1
,2
,3
]
Whittemore, Scott R.
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h-index: 0
机构:
Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA
Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USAUniv Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
Whittemore, Scott R.
[1
,2
,3
]
机构:
[1] Univ Louisville, Kentucky Spinal Cord Injury Res Ctr, Louisville, KY 40292 USA
[2] Univ Louisville, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA
[3] Univ Louisville, Dept Neurol Surg, Louisville, KY 40292 USA
Advances in spinal cord injury (SCI) research are dependent on quality animal models, which in turn rely on sensitive outcome measures able to detect functional differences in animals following injury. To date, most measurements of dysfunction following SCI rely either on the subjective rating of observers or the slow throughput of manual gait assessment. The present study compares the gait of normal and contusion-injured mice using the TreadScan (R) system. TreadScan utilizes a transparent treadmill belt and a high-speed camera to capture the footprints of animals and automatically analyze gait characteristics. Adult female C57B1/6 mice were introduced to the treadmill prior to receiving either a standardized mild, moderate, or sham contusion spinal cord injury. TreadScan gait analyses were performed weekly for 10 weeks and compared with scores on the Basso Mouse Scale (BMS). Results indicate that this software successfully differentiates sham animals from injured animals on a number of gait characteristics, including hindlimb swing time, stride length, toe spread, and track width. Differences were found between mild and moderate contusion injuries, indicating a high degree of sensitivity within the system. Rear track width, a measure of the animal's hindlimb base of support, correlated strongly both with spared white matter percentage and with terminal BMS. TreadScan allows for an objective and rapid behavioral assessment of locomotor function following mild-moderate contusive SCI, where the majority of mice still exhibit hindlimb weight support and plantar paw placement during stepping.
机构:
Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Amende I.
;
Kale A.
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CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Kale A.
;
McCue S.
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CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
McCue S.
;
Glazier S.
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CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Glazier S.
;
Morgan J.P.
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Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Morgan J.P.
;
Hampton T.G.
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机构:
Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Hao, JX
;
Xu, XJ
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机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Xu, XJ
;
Jacoby, AS
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机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Jacoby, AS
;
Shine, J
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机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Shine, J
;
Crawley, JN
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机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Crawley, JN
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Iismaa, T
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机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Iismaa, T
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Wiesenfeld-Hallin, Z
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机构:
Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, SwedenHuddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
机构:
Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Amende I.
;
Kale A.
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h-index: 0
机构:
CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Kale A.
;
McCue S.
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h-index: 0
机构:
CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
McCue S.
;
Glazier S.
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h-index: 0
机构:
CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Glazier S.
;
Morgan J.P.
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h-index: 0
机构:
Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Morgan J.P.
;
Hampton T.G.
论文数: 0引用数: 0
h-index: 0
机构:
Division of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
CuraVita Corporation, BostonDivision of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Hao, JX
;
Xu, XJ
论文数: 0引用数: 0
h-index: 0
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Xu, XJ
;
Jacoby, AS
论文数: 0引用数: 0
h-index: 0
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Jacoby, AS
;
Shine, J
论文数: 0引用数: 0
h-index: 0
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Shine, J
;
Crawley, JN
论文数: 0引用数: 0
h-index: 0
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Crawley, JN
;
Iismaa, T
论文数: 0引用数: 0
h-index: 0
机构:Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden
Iismaa, T
;
Wiesenfeld-Hallin, Z
论文数: 0引用数: 0
h-index: 0
机构:
Huddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, SwedenHuddinge Univ Hosp, Karolinska Inst, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Stockholm, Sweden