Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7

被引：46

作者：

Chaouki, Wahid ^{[1
]}

Leger, David Y. ^{[2
]}

Eljastimi, Jamila ^{[3
]}

Beneytout, Jean-Louis ^{[2
]}

Hmamouchi, Mohamed ^{[4
]}

机构：

[1] Natl Inst Oncol, Lab Serv, Rabat, Morocco

[2] Fac Pharm, Biochem Lab, Limoges, France

[3] Fac Med & Pharm, Biochem Lab, Rabat, Morocco

[4] Natl Inst Med & Aromat Plants, Taounate, Morocco

来源：

PHARMACEUTICAL BIOLOGY | 2010年 / 48卷 / 03期

关键词：

Antiproliferative effect; Aristolochia baetica; MCF-7; cells; MTT assay; Origanum compactum; BETULINIC ACID; CONSTITUENTS; DISCOVERY; STEM; ROOT;

D O I：

10.3109/13880200903096588

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Aristolochia baetica L. (Aristolochiaceae) and Origanum compactum Benth. (Lamiaceae) are native plants of Morocco used in traditional medicine. In order to systematically evaluate their potential activity on human breast cancer, four different polarity extracts from each plant were assessed in vitro for their antiproliferative effect on MCF-7 cells. As a result, several extracts of those plants showed potent cell proliferation inhibition on MCF-7 cells. Chloroform extract of A. baetica (IC50: 216.06 +/- 15 mu g/mL) and ethyl acetate of O. compactum (IC50: 279.51 +/- 16 mu g/mL) were the most active. Thin layer chromatography examination of the bioactive extracts of A. baetica and O. compactum showed the presence of aristolochic acid and betulinic acid, respectively. These results call for further studies of these extracts.</.

引用

页码：269 / 274

页数：6

共 26 条

[1]

Abdulaev FI, 1993, PHARM THERAPEUTICS N, P345

[2]

BELLAKHDAR J, 1988, PLANTA MED, V54

[3]

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors [J].