In vivo confocal and multiphoton microendoscopy

被引：101

作者：

Kim, Pilhan ^{[1
]}

Puoris'haag, Mehron

Cote, Daniel

Lin, Charles P.

Yun, Seok H.

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2008年 / 13卷 / 01期

关键词：

endoscopy; imaging; fluorescence; microscopy; confocal optics; multiphoton processes;

D O I：

10.1117/1.2839043

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The ability to conduct high-resolution fluorescence imaging in internal organs of small animal models in situ and over time can make a significant impact in biomedical research. Toward this goal, we developed a real-time confocal and multiphoton endoscopic imaging system. Using 1-mm-diameter endoscopes based on gradient index lenses, we demonstrate video-rate multicolor multimodal imaging with cellular resolution in live mice. (C) 2008 Society of Photo-Optical Instrumentation Engineers.

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页数：3

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