Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus

被引：191

作者：

Christensen, Dan P.

Dahllof, Mattias

Lundh, Morten

Rasmussen, Daniel N.

Nielsen, Mette D.

Billestrup, Nils

Grunnet, Lars G.

Mandrup-Poulsen, Thomas ^{[1
,2
,3
]}

机构：

[1] Univ Copenhagen, Panum Inst, Dept Biomed Sci, Ctr Med Res Methodol, DK-2200 Copenhagen N, Denmark

[2] Hagedorn Res Inst, Dept Diabet Inflammat, Gentofte, Denmark

[3] Karolinska Inst, Dept Med & Surg, Stockholm, Sweden

来源：

MOLECULAR MEDICINE | 2011年 / 17卷 / 5-6期

关键词：

ENDOPLASMIC-RETICULUM STRESS; PANCREATIC BETA-CELLS; INSULIN GENE-TRANSCRIPTION; TUMOR-NECROSIS-FACTOR; PRO-INFLAMMATORY CYTOKINES; IL-1 RECEPTOR ANTAGONIST; DNA-BINDING ACTIVITY; DOWN-REGULATION; VALPROIC ACID; PROINFLAMMATORY CYTOKINES;

D O I：

10.2119/molmed.2011.00021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-lp as a key mediator of insulin resistance and beta-cell failure. In addition to improving insulin resistance and preventing beta-cell inflammatory damage, there is evidence of genetic association between diabetes and histone deacetylases (HDACs): and HDAC inhibitors (HDACi) promote beta-cell development, proliferation, differentiation and function and positively affect late diabetic microvascular complications. Here we review this evidence and propose that there is a strong rationale for preclinical studies and clinical trials with the aim of testing the utility of HDACi as a novel therapy for diabetes. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: http://www.molmed.org doi: 10.2119/molmed.2011.00021

引用

收藏

页码：378 / 390

页数：13

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