Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

被引:117
作者
Frasca, D [1 ]
Van der Put, E [1 ]
Riley, RL [1 ]
Blomberg, BB [1 ]
机构
[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA
关键词
D O I
10.4049/jimmunol.172.4.2155
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The capacity to class switch the IgH chain is critical to the effectiveness of humoral immune responses. We show that in vitro-stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes (IgG1, G2a, G3, and E), class switch recombination (CSR), and induction of the E2A-encoded transcription factor E47. E47 has previously been shown to be. required for CSR, at least in part via expression of the activation-induced cytidine deaminase. Our studies show that impaired induction of E47, and subsequently activation-induced cytidine deaminase, contribute to poor CSR and production of secondary isotypes in senescence.
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收藏
页码:2155 / 2162
页数:8
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