ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression

被引：33

作者：

Engreitz, Jesse M. ^{[1
,2
]}

Chen, Rong ^{[1
,3
]}

Morgan, Alexander A. ^{[1
,3
,4
]}

Dudley, Joel T. ^{[1
,3
,4
]}

Mallelwar, Rohan ^{[5
]}

Butte, Atul J. ^{[1
,3
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pediat, Div Syst Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Bioengn, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Lucile Packard Childrens Hosp, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Biomed Informat Training Program, Stanford, CA 94305 USA

[5] Optra Syst Pvt Ltd, Pune 411005, Maharashtra, India

来源：

BIOINFORMATICS | 2011年 / 27卷 / 23期

关键词：

SIGNATURES; DISCOVERY; GENES; CELLS;

D O I：

10.1093/bioinformatics/btr548

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We introduce ProfileChaser, a web server that allows for querying the Gene Expression Omnibus based on genomewide patterns of differential expression. Using a novel, content-based approach, ProfileChaser retrieves expression profiles that match the differentially regulated transcriptional programs in a user-supplied experiment. This analysis identifies statistical links to similar expression experiments from the vast array of publicly available data on diseases, drugs, phenotypes and other experimental conditions.

引用

页码：3317 / 3318

页数：2

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