Marine invertebrate genome sequences and our evolving understanding of animal immunity

被引：47

作者：

Rast, Jonathan P. ^{[1
,2
]}

Messier-Solek, Cynthia ^{[1
]}

机构：

[1] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Immunol, Toronto, ON M4N 3M5, Canada

来源：

BIOLOGICAL BULLETIN | 2008年 / 214卷 / 03期

关键词：

D O I：

10.2307/25470669

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Animal immunity is under intense evolutionary pressure, and the mechanisms that carry out recognition and elimination of pathogens are among the most rapidly evolving genetic systems. It is increasingly apparent that this has led to the emergence of novel molecular mechanisms not only among vertebrates, where immunity is by far best characterized, but also across invertebrate phyla. This propensity for rapid divergence has been a serious obstacle for progress in the field of comparative immunology. The variety of recent genome sequences from marine invertebrates representing new phyla offers a means to move for-ward in this area. Genome sequences provide much improved sensitivity for the detection of gene homologs and a framework for unbiased computational and experimental searches for novel immune mediators. Furthermore, new genomes now offer a more complete and unbiased view of immunity across bilaterian phyla, especially among deuterostomes. In this review we summarize these findings with particular attention toward immunity in Strongylocentrotus purpuratus, the purple sea urchin, and outline the changing perspective on the evolution of deuterostome immunity.

引用

页码：274 / 283

页数：10

共 57 条

[41]

Pancer Z, 2001, ADV EXP MED BIOL, V484, P31

[42] Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:: Mutations in Tlr4 gene [J].

Poltorak, A ;

He, XL ;

Smirnova, I ;

Liu, MY ;

Van Huffel, C ;

Du, X ;

Birdwell, D ;

Alejos, E ;

Silva, M ;

Galanos, C ;

Freudenberg, M ;

Ricciardi-Castagnoli, P ;

Layton, B ;

Beutler, B .

SCIENCE, 1998, 282 (5396) :2085-2088

[43] Review - Genomic insights into the immune system of the sea urchin [J].

Rast, Jonathan P. ;

Smith, L. Courtney ;

Loza-Coll, Mariano ;

Hibino, Taku ;

Litman, Gary W. .

SCIENCE, 2006, 314 (5801) :952-956

[44] The evolution of vertebrate Toll-like receptors [J].

Roach, JC ;

Glusman, G ;

Rowen, L ;

Kaur, A ;

Purcell, MK ;

Smith, KD ;

Hood, LE ;

Aderem, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (27) :9577-9582

[45] The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus [J].

Robertson, Anthony J. ;

Croce, Jenifer ;

Carbonneau, Seth ;

Voronina, Ekaterina ;

Miranda, Esther ;

McClay, David R. ;

Coffman, James A. .

DEVELOPMENTAL BIOLOGY, 2006, 300 (01) :321-334

[46] Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase [J].

Rogozin, Igor B. ;

Iyer, Lakshminarayan M. ;

Liang, Lizhi ;

Glazko, Galina V. ;

Liston, Victoria G. ;

Pavlov, Youri I. ;

Aravind, L. ;

Pancer, Zeev .

NATURE IMMUNOLOGY, 2007, 8 (06) :647-656

[47] Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion [J].

Rosenstiel, Philip ;

Sina, Christian ;

End, Caroline ;

Renner, Marcus ;

Lyer, Stefan ;

Till, Andreas ;

Hellmig, Stephan ;

Nikolaus, Susanna ;

Foelsch, Ulrich R. ;

Helmke, Burkhard ;

Autschbach, Frank ;

Schirmacher, Peter ;

Kioschis, Petra ;

Hafner, Mathias ;

Poustka, Annemarie ;

Mollenhauer, Jan ;

Schreiber, Stefan .

JOURNAL OF IMMUNOLOGY, 2007, 178 (12) :8203-8211

[48]

RUST JP, 2000, CURR TOP MICROBIOL I, V248, P3

[49] Dynamic evolution of the innate immune system in Drosophila [J].

Sackton, Timothy B. ;

Lazzaro, Brian P. ;

Schlenke, Todd A. ;

Evans, Jay D. ;

Hultmark, Dan ;

Clark, Andrew G. .

NATURE GENETICS, 2007, 39 (12) :1461-1468

[50]

Sarrias MR, 2004, CRIT REV IMMUNOL, V24, P1

← 1 2 3 4 5 6 →