Reactivation of mutant p53: a new strategy for cancer therapy

被引：50

作者：

Selivanova, G ^{[1
]}

Kawasaki, T ^{[1
]}

Ryabchenko, L ^{[1
]}

Wiman, KG ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Microbiol & Tumor Biol, S-17177 Stockholm, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 1998年 / 8卷 / 05期

关键词：

cancer therapy; C-terminus; mutant p53; p53; regulation; reactivation;

D O I：

10.1006/scbi.1998.0099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The specific DNA binding activity of p53 is crucial for its tumor suppression function. Naturally occurring mutant forms of p53 are deficient for specific DNA binding. However, several studies have indicated that their specific DNA binding can be reactivated. Short peptides derived from tie p53 C-terminus can reactivate at least some mutant p53 proteins and trigger a p53-dependent biological response. These results may provide the basis for the design of p53-reactivating anti-cancer drags.

引用

页码：369 / 378

页数：10

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