Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways

被引：166

作者：

Anitei, Mihaela ^{[1
]}

Hoflack, Bernard ^{[1
]}

机构：

[1] Tech Univ Dresden, Ctr Biotechnol, D-01307 Dresden, Germany

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 01期

关键词：

TRANS-GOLGI NETWORK; CLATHRIN-MEDIATED ENDOCYTOSIS; F-BAR PROTEINS; DEPENDENT ACTIN POLYMERIZATION; COATED VESICLE FORMATION; WASP-WIP COMPLEX; MOLECULAR MOTORS; PLASMA-MEMBRANE; ARP2/3; COMPLEX; MYOSIN-I;

D O I：

10.1038/ncb2409

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transport carriers regulate membrane flow between compartments of the secretory and endocytic pathways in eukaryotic cells. Carrier biogenesis is assisted by microtubules, actin filaments and their associated motors that link to membrane-associated coats, adaptors and accessory proteins. We summarize here how the biochemical properties of membranes inform their interactions with cytoskeletal regulators. We also discuss how the forces generated by the cytoskeleton and motor proteins alter the biophysical properties and the shape of membranes. The interplay between the cytoskeleton and membrane proteins ensures tight spatial and temporal control of carrier biogenesis, which is essential for cellular homeostasis.

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页码：11 / 19

页数：9

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