Viscero-somatic reflexes in referred pain areas evoked by capsaicin stimulation of the human gut

被引：37

作者：

Arendt-Nielsen, Lars ^{[1
]}

Schipper, Klaus-Peter ^{[2
]}

Dimcevski, Georg ^{[2
]}

Sumikura, Hiroyuki ^{[1
]}

Krarup, Anne Lund ^{[2
]}

Giamberardino, Maria Adele ^{[3
]}

Drewes, Asbjorn Mohr ^{[1
,2
]}

机构：

[1] Aalborg Univ, Ctr Sensory Motor Interact, Lab Expt Pain Res, DK-9220 Aalborg E, Denmark

[2] Aalborg Univ Hosp, Dept Gastroenterol, Ctr Visceral Biomech & Pain, Aalborg, Denmark

[3] Univ G dAnnunzio, Pathophysiol Pain Lab, CeSI, GD Annunzio Fdn, Chieti, Italy

来源：

EUROPEAN JOURNAL OF PAIN | 2008年 / 12卷 / 05期

关键词：

capsaicin; gut; experimental; pain; vaso-motor reflexes; human; thermography; laser doppler flowmetry;

D O I：

10.1016/j.ejpain.2007.08.010

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

The interaction between visceral pain and the sympathetic nervous system is only sparsely investigated in quantitative human studies. Referred visceral pain can be evoked experimentally by application of substances such as capsaicin (the pungent substance of chilli pepper) to the gut. The aim of the present study was to induce referred visceral pain from the small and large intestine in 32 volunteers via the stoma] opening in patients with ileo- or colostomy and quantify the viscero-somatic reflex responses in these referred pain areas by thermography and laser doppler flowmetry. Capsaicin evoked pain and referred pain areas in all subjects. In the referred pain area, the temperature increased by approximately 0.6 degrees C (P < 0.001) and the blood flow by approximately 35 AU (P < 0.001). Saline was used in a control experiment, and no temperature and blood flow changes were found. The present quantitative human study of viscero-somatic reflexes showed dramatic sympathetic responses in the referred pain areas after experimentally induced gut pain. (C) 2007 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.

引用

页码：544 / 551

页数：8

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[1]

Is female predominance in irritable bowel syndrome related to fibromyalgia? [J].