A convenient route to cyanoguanidines

被引：10

作者：

Novák, L

Hanania, M

Kovács, P

Kovács, CE

Kolonits, P

Szántay, C

机构：

[1] Tech Univ Budapest, Inst Organ Chem, H-1111 Budapest, Hungary

[2] Cent Res Inst Chem, H-1525 Budapest, Hungary

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 10期

关键词：

D O I：

10.1080/00397919908086163

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and versatile method for the preparation of cyanoguanidines 7 from amines 3 and isothiocyanates 4 via a methylation, cyanamide-treatment sequence is described.

引用

页码：1757 / 1766

页数：10

共 13 条

[1] Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes:: Correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies [J].

Atwal, KS ;

Grover, GJ ;

Lodge, NJ ;

Normandin, DE ;

Traeger, SC ;

Sleph, PG ;

Cohen, RB ;

Bryson, CC ;

Dickinson, KEJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (03) :271-275

[2] A FACILE SYNTHESIS OF CYANOGUANIDINES FROM THIOUREAS [J].

ATWAL, KS ;

AHMED, SZ ;

OREILLY, BC .

TETRAHEDRON LETTERS, 1989, 30 (52) :7313-7316

[3] Cardioselective antiischemic ATP-sensitive potassium channel openers .4. Structure-activity studies on benzopyranylcyanoguanidines: Replacement of the benzopyran portion [J].

Atwal, KS ;

Ferrara, FN ;

Ding, CZ ;

Grover, GJ ;

Sleph, PG ;

Dzwonczyk, S ;

Baird, AJ ;

Normandin, DE .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) :304-313

[4]

CURD FHS, 1948, J CHEM SOC, P1620

[5] SYNTHESIS OF N-ALKYL-N'-CYANO-N''-4-PYRIDYLGUANIDINES FROM 4-PYRIDYLDITHIOCARBAMIC ACID VIA N-ALKYL-N'-4-PYRIDYLTHIOUREAS, OR VIA 4-PYRIDYLCYANIMINOTHIOCARBAMIC ACID [J].

HANSEN, ET ;

PETERSEN, HJ .

SYNTHETIC COMMUNICATIONS, 1984, 14 (13) :1275-1283

[6]

LECHER HZ, 1946, Patent No. 2455894

[7] STRUCTURE ACTIVITY STUDIES OF POTASSIUM CHANNEL OPENING IN PINACIDIL-TYPE CYANOGUANIDINES, NITROETHENEDIAMINES, THIOUREAS, AND UREAS [J].

MANLEY, PW ;

QUAST, U .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (12) :2327-2340

[8]

MCBURNEY A, 1987, J PHARM SCI, V12, P940

[9]

MESTRES R, 1980, SYNTHESIS-STUTTGART, P755

[10] SYNTHESIS AND HYPOTENSIVE ACTIVITY OF N-ALKYL-N'-CYANO-N'-PYRIDYLGUANIDINES [J].

PETERSEN, HJ ;

NIELSEN, CK ;

ARRIGONIMARTELLI, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (08) :773-781

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