The antiproliferative effect of acridone alkaloids on several cancer cell lines

被引：52

作者：

Kawaii, S

Tomono, Y

Katase, E

Ogawa, K

Yano, M ^{[1
]}

Takemura, Y

Motoharu, J

Ito, C

Furukawa, H

机构：

[1] Natl Inst Fruit Tree Sci, Shimizu, Shizuoka 4240204, Japan

[2] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[3] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期

关键词：

D O I：

10.1021/np980504z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure-activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-l and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones.

引用

页码：587 / 589

页数：3

共 22 条

[21] ACRIDONE ALKALOIDS .9. CHEMICAL-CONSTITUENTS OF GLYCOSMIS-CITRIFOLIA (WILLD) LINDL STRUCTURES OF NOVEL LINEAR PYRANOACRIDONES, FUROACRIDONES, AND OTHER NEW ACRIDONE ALKALOIDS [J].