Extracellular release of antigenic proteins by Helicobacter pylori

被引：88

作者：

Cao, P

McClain, MS

Forsyth, MH

Cover, TL ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Div Infect Dis, Med Ctr N A3310,Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

[3] Dept Vet Affairs Med Ctr, Nashville, TN 37232 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 06期

关键词：

D O I：

10.1128/IAI.66.6.2984-2986.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.

引用

收藏

页码：2984 / 2986

页数：3

相关论文

共 26 条

[1]

DNA DIVERSITY AMONG CLINICAL ISOLATES OF HELICOBACTER-PYLORI DETECTED BY PCR-BASED RAPD FINGERPRINTING [J].

AKOPYANZ, N ;

BUKANOV, NO ;

WESTBLOM, TU ;

KRESOVICH, S ;

BERG, DE .

NUCLEIC ACIDS RESEARCH, 1992, 20 (19) :5137-5142

[2]

STRUCTURAL COMPARISON OF UREASE AND A GROEL ANALOG FROM HELICOBACTER-PYLORI [J].

AUSTIN, JW ;

DOIG, P ;

STEWART, M ;

TRUST, TJ .

JOURNAL OF BACTERIOLOGY, 1992, 174 (22) :7470-7473

[3]

COVER TL, 1992, J BIOL CHEM, V267, P10570

[4]

Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly [J].

Cover, TL ;

Hanson, PI ;

Heuser, JE .

JOURNAL OF CELL BIOLOGY, 1997, 138 (04) :759-769

[5]

Cover TL, 1996, ADV INTERNAL MED, V41, P85

[6]

WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD [J].

FLEISCHMANN, RD ;

ADAMS, MD ;

WHITE, O ;

CLAYTON, RA ;

KIRKNESS, EF ;

KERLAVAGE, AR ;

BULT, CJ ;

TOMB, JF ;

DOUGHERTY, BA ;

MERRICK, JM ;

MCKENNEY, K ;

SUTTON, G ;

FITZHUGH, W ;

FIELDS, C ;

GOCAYNE, JD ;

SCOTT, J ;

SHIRLEY, R ;

LIU, LI ;

GLODEK, A ;

KELLEY, JM ;

WEIDMAN, JF ;

PHILLIPS, CA ;

SPRIGGS, T ;

HEDBLOM, E ;

COTTON, MD ;

UTTERBACK, TR ;

HANNA, MC ;

NGUYEN, DT ;

SAUDEK, DM ;

BRANDON, RC ;

FINE, LD ;

FRITCHMAN, JL ;

FUHRMANN, JL ;

GEOGHAGEN, NSM ;

GNEHM, CL ;

MCDONALD, LA ;

SMALL, KV ;

FRASER, CM ;

SMITH, HO ;

VENTER, JC .

SCIENCE, 1995, 269 (5223) :496-512

[7]

ANALYSIS OF GENETIC DIVERSITY IN CYTOTOXIN-PRODUCING AND NON-CYTOTOXIN-PRODUCING HELICOBACTER-PYLORI STRAINS [J].

GARNER, JA ;

COVER, TL .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (01) :290-293

[8]

Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: Extensive allelic diversity and recombinational population structure [J].

Go, MF ;

Kapur, V ;

Graham, DY ;

Musser, JM .

JOURNAL OF BACTERIOLOGY, 1996, 178 (13) :3934-3938

[9]

BISULFITE OR SULFITE INHIBITS GROWTH OF HELICOBACTER-PYLORI [J].

HAWRYLIK, SJ ;

WASILKO, DJ ;

HASKELL, SL ;

GOOTZ, TD ;

LEE, SE .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (03) :790-792

[10]

Variability of gene order in different Helicobacter pylori strains contributes to genome diversity [J].

Jiang, Q ;

Hiratsuka, K ;

Taylor, DE .

MOLECULAR MICROBIOLOGY, 1996, 20 (04) :833-842